Blodet.dkThis homepage presents information from the Research Laboratory at the Department of Haematology, Aalborg Hospital, Aarhus University.
The Research Laboratory was established during 2005-2007. Competent staff members have been employed in accordance with the research strategy within a visible organization and management structure.
The scientific goals are to achieve new insight on the mechanisms concerning the haematological cancer diseases with focus on the human B-cell malignancies and associated disorders.
The laboratory is a section of the Haematology Research Department and is located at Aalborg Hospital Science and Innovation Centre with core functions for gene array and protein array technologies as well as core function for multiparametric flow cytometry and cell sorting. The Bio-Laboratory (Biobank), the Clinical Trial Unit and the Clinical Department are located at Medicinerhuset (the Medical Centre). News... |  
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29/3/12 Workshop held 14/03 2012 3rd EMN course on Minimal Residual Disease (MRD) at the Research laboratory of the Department of Haematology, Aalborg University Hospital, Denmark.
“A laboratory training session on the MRD protocol for multiparametric flow cytometry for academics and technicians of European institutions participating in EMN-02 Clinical Trial”.
Headed by Prof. Hans E Johnsen (Denmark) and Prof. Alberto Orfao Spain).
Instructors: PhD Alexander Schmitz (Denmark) and Associate Prof. Martin Perez Andres (Spain).
The course was held on behalf of the EMN.
More about the course and the EMN can be found here. | | | 6/2/12 Poster presentation On 13.01.2012 Kim Steve Bergkvist presented a poster at the PhD day Faculty of Health Sciences Aarhus University:
GENERATION OF A DOCUMENTED TECHNIQUE FOR GENETIC STUDIES OF SMALL DISCRETE POPULATIONS OF NORMAL AND MALIGNANT B CELLS
He won the prize for best poster session in his section
See the presentation 
| | | 6/2/12 Grant received
Medical Student Simon Mylius has received DKK 9.000 from the foundation: ”Speciallæge Heinrich Kopps Legat” to the project: "Effects of Cryopreservation - A Validation Study of Banking B-cell Subsets” | | | 6/2/12 Grant received
Post doc Julie Støve Bødker has received DKK 9.000 from the foundation: ”Speciallæge Heinrich Kopps Legat” to the project: "Identification of the genetic background i diffuse large B-cell lymphoma and integration of such with gene expression arrays to identify new tumor suppressor or oncogenes.” | | | 6/2/12 Master Thesis Defence
Sophie Bech Rasmussen defended her master thesis on 21st of December 2012. The title of the thesis was "CYTOGENETIC PROFILING OF B-CELL LYMPHOMAS".
| | | 6/2/12 Christmas photo  | | | 5/1/12 Boardmembership of the Danish Society of Cancer Research
Karen Dybkær has become a boardmember of the Danish Society of Cancer Research.
http://www.dscf.dk/ | | | 15/12/11 PhD Thesis Defense
On Thursday 22 December 2011 Anders Petersen will be defending his PhD thesis.
MSc, PhD student, Anders Petersen from the Haematology Research Laboratory will be defending his PhD thesis "MicroRNA targets in Diffuse Large B-cell lymphoma".
Registration: Registration is not necessary.
Time: 13.00-15.00 p.m.
Place: Forskningens Hus, Auditorium
Please note: The defence is open to the public
Organizer: Aalborg Hospital
| | | 15/11/11 Management seminar held at Klitgaarden
A management seminar was held at Klitgaarden from 28 September – 1 October 2011.
Hans Johnsen, Karen Dybkær, Martin Bøgsted, Mette Nyegaard, Alex Schmitz, Julie Støve Bødker and Martin Perez attended the seminar. 
| | | 25/10/11 Presentation the 12 October at the 6th Myeloma Workshop "Modern technologies in research of monoclonal gammopathies", Brno, Czech Republic.
Alexander Schmitz held a presentation entitled "Human secondary normal tissue B-cell subpopulations. Identification, isolation and characterization" | | | 25/10/11 Presentation the 14 October at the DSFCM's 47. mode "Current projects using flow cytometry", Aarhus, Denmark
Alexander Schmitz held a presentation entitled "Human secondary normal tissue B-cell subpopulations. Identification, isolation and characterization" | | | 25/10/11 Master Thesis Defence
Annie Bendtsen defended her master thesis on 24th of october, at 9.30 hours, at Meeting room 2.1. The title of the thesis was "Analysis of Pax5's promoters and alternative transcripts in subtypes of diffuse large B cell lymphoma"
| 14/10/11 New publication
Andersen TB, Jødal L, Boegsted M, Erlandsen EJ, Morsing A, Frøkiær J, Brøchner-Mortensen J
"GFR prediction from cystatin C and creatinine in children: Effect of including body cell mass"
The paper has been accepted for publication in American Journal of Kidney Diseases. | | | 14/10/11 Courses held 21/09 and 27/09
EMN course on Minimal Residual Disease (MRD)at the Research laboratory of the department of Haematology, Aalborg University Hospital, Denmark “A laboratory training session on the MRD protocol for multiparametric flow cytometry for academics and technicians of European institutions participating in EMN-02 Clinical Trial”
Headed by Prof. Hans E Johnsen (Denmark) and Prof. Alberto Orfao Spain)
Instructors: PhD Alexander Schmitz (Denmark) and Associate Prof. Martin Perez Andres (Spain) The course was held on behalf of the EMN.
More about the course and the EMN can be found here: http://www.myeloma-europe.org/index.php?emn-021 | | | 17/08/11 New publications
Demontis D, Nyegaard M, Christensen JH, Severinsen J, Hedemand A, Hansen T, Werge T, Mors O, Børglum AD.
"The gene encoding the melanin-concentrating hormone receptor 1 is associated with schizophrenia in a Danish case control sample."
Psychiat Genet (2011) Accepted for publication
Gregersen N, Dahl HA, Buttenschøn HN, Nyegaard M, Hedemand A, Als TD, Wang AG, Joensen S, Woldby D, Koefoed P, Kristensen AS, Kruse TA, Børglum A, Mors O.
"ACCN1 a Potential Candidate Gene for Panic Disorder."EJHG (2011) Accepted for publication
Haubek D, Gjørup H, Jensen LG, Junker I, Nyegaard M, Børglum AD, Poulsen S, Hertz JM.
"Limited Phenotypic Variation of Hypocalcified Amelogenesis Imperfecta in a Danish Five-Generation Family with a Novel FAM83H Nonsense Mutation. Int J Paediatr Dent. (2011)"
Accepted for publication (publication from Aarhus University)
Nexø BA, Christensen T, Frederiksen J, Møller-Larsen A, Oturai AB, Villesen P, Hansen B, Nissen KK, Laska MJ, Petersen TS, Bonnesen S, Hedemand A, Wu T, Wang X, Zhang X, Brudek T, Maric R, Søndergaard HB, Sellebjerg F, Brusgaard K, Kjeldbjerg AL, Rasmussen HB, Nielsen AL, Nyegaard M, Petersen T, Børglum AD, Pedersen FS.
"The etiology of Multiple Sclerosis: Genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1."
PLOS ONE. (2011) Feb 2;6(2):e16652. (publication from Aarhus University)
Demontis D*; Nyegaard, Mette*; Buttenschon, Henriette*; Hedemand, Anne; Pedersen, Carsten; Grove, Jakob; Flint, Tracey; Nordentoft, Merete; Werge, Thomas; Hougaard, David; Sørensen, Karina; Yolken, Robert; Mors, Ole; Børglum, Anders; Mortensen, Preben.
"Association of GRIN1 and GRIN2A-D with schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk." *Shared first authors.
Am J Med Genet B. (2011). Accepted for publication. | | | 28/06/11 Grant received
PhD student Steffen Falgreen Larsen has received DKK 72.000 from the ”Region Nordjyllands Sundhedsvidenskabelige Forskningsfond” to the project: "Statistical Models Studying Potential Biomarkers for Prediction of Chemotherapy Outcome". | | | 28/06/11 Grant received
PhD student Maria Rodrigo-Domingo has received DKK 72.000 from the ”Region Nordjyllands Sundhedsvidenskabelige Forskningsfond” to the project: "Statistical methods for repeated measures of exon array data and the systems biology of B-cell differentiation".
| | | 21/06/11 Master thesis defence
Hanne Munkøe will defend her master thesis on 23 June 2011, at 13 hours, at Forskningens Hus.
The title of the thesis is "Regulation of AICDA by miR-155 and miR-181b in human naive stimulated B-cells and DLBCL" | | | 21/06/11 Grant received Post doc Julie Støve Bødker has received DKK 50.531 from the ”Region Nordjyllands Sundhedsvidenskabelige Forskningsfond” to the project: Identification of the genetic background in diffuse large B-cell lymphoma and integration of such with gene expression to identify new tumor suppressor or oncogenes”. | | | | 21/06/11 New publication in press: Krag Kjeldsen M, Perez-Andres M, Schmitz A, Johansen P, Boegsted M, Nyegaard M, Gaihede M, Bukh A, Johnsen HE, Orfao A and Dybkaer K
"Multiparametric Flow Cytometry for Identification and Fluorescence Activated Cell Sorting (FACS) of Five Distinct B-cell Subpopulations in Normal Tonsil Tissue"
The publication has been accepted for publication in American Journal of Clinical Pathology. | | | | 21/06/11 New publication in press: Nielsen KR, Steffensen R, Boegsted M, Baech J, Lundby-Christensen S, Hetland ML, Krintel SB, Johnsen HE, Nyegaard M and Johansen J
"Promoter polymorphisms in the Chitinase 3-Like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects"
The publication has been accepted for publication in Arthritis Research & Therapy | | | | 21/06/11 The Bioinformatics Roadshow - Copenhagen, Denmark: Maria Rodrigo-Domingo, Steffen Falgreen Larsen og Martin Bøgsted have attended "The Bioinformatics Roadshow" in Copenhagen with lectures given by The EMBL-EBI (European Molecular Biological Institute, European Bioinformatics Institute), June 16-17, 2011. See the programme and presentations at http://www.ebi.ac.uk/training/roadshow/110616_copenhagen.html | | | | 21/06/11 Grants received Maria Rodrigo-Domingo and Steffen Falgreen Larsen have received a travel a bursary grant from the EMBL-EBI (European Molecular Biological Institute, European Bioinformatics Institute) for participation in The Bioinformatics Roadshow in Copenhagen, June 16-17, 2011. | | | | 23/05/11 Grant received Associate Professor Mette Nyegaard has received DKK 11.000 from Aarhus University (Kompetencefonden) to participate in a 5 day course in Research leadership, May/June 2011, Kibæk, Denmark. | | | | 19/05/11 The 13th International Myeloma Workshop (IMW) 2011 Hans E. Johnsen, Martin Bøgsted and Alexander Schmitz attended the 13th International Myeloma Workshop (IMW) 2011 in Paris, France (03.05 - 06.05) and presented 2 posters.
Bøgested et.al.: "Identification of potential predictive gene list for melphalan resistence by drug screen of b-cell cancer cell lines"
Schmitz et.al.: "B-cell subpopulations from normal human secondary lymphoid tissues with specific gene expression profiles and phenotypes: Imapct on Myeloma"
Corresponding abstracts (P050, P093) are published in 'Hematologica' (ISSN 0390-6078). | | | | 09/05/11 New publication Boegsted M, Holst JM, Fogd K, Falgreen S, Sørensen S, Schmitz A, Bukh A, Johnsen HE, Nyegaard M, Dybkaer K (2011) Generation of a Predictive Melphalan Resistance Index by Drug Screen of B-Cell Cancer Cell Lines.
The paper has been published in PLoS ONE 6(4): e19322. doi:10.1371/journal.pone.0019322. See the paper here.
| | | | 27/04/11 Strategy meeting and B-cell subset workshop at Klitgaarden, Skagen On March 30th to April 1st Karen Dybkær organized a scientific meeting at Klitgaarden – Refugium in Skagen. The meeting concerned the future strategy of the department and a workshop on B-cell subsets.
Participants: Karen Dybkær, Mette Nyegaard, Martin Bøgsted, Hans E Johnsen, Alexander Schmitz, Suzette Sørensen.
| | | | 11/04/11 Basic PhD course in scientific research Torben Lüth Anderson was participating in the "Basic PhD course in scientific research" at Århus University from 15-17 marts.
The aim of this course was to introduce the concepts and content of the PhD education for new PhD students. | | | | 11/04/11 Grant received Associate Professor Mette Nyegaard has received DKK 20.000 kr from AUFF (Aarhus University Research Fund) based on the project "DNA mutation og kræft - betydning af ny-identificeret gen-mutation for patienter med lymfeknudekræft"" | | | | 04/04/11 Presentation at the 12th DMSG ”Dansk Myelomatose Studie Gruppe” meeting Presentation at the 12th DMSG ”Dansk Myelomatose Studie Gruppe” meeting at Aalborg Sygehus Syd.
The Department of Haematology had 3 oral presentations from the PhD students (Marts 25, 2011).
1) Multiple parameters FACS for isolating of human B cell subpopulations from normal and malignant lymphoid tissue – Malene Krag Kjeldsen
2) Gene expression and alternatively spliced genes in Multiple Myeloma patients – Kim Steve Bergkvist
3) Stable Selection of Multiple Myeloma Subclass Signatures – Steffen Falgreen Larsen
| | | | 04/04/11 Annual Meeting in DAHFO On 16-18 March Dansk Hæmatologisk Forskerskole, DAHFO, held an annual meeting at Hindsgavl Slot with Karen Dybkær Sørensen and Hans E Johnsen as organizers.
The title of the meeting was “State of the Art – Pathogenesis, Novel Technologies and Clinical Trials in Haematological Malignancies”.
15 invited professors and associate professors, with great knowledge within the areas pathogenesis for leukaemia, lymphoma and bone marrow cancer and methods for a.o. diagnostics and general research as well as clinical protocols, gave lectures.
The programme is available at the website of Dansk Hæmatologisk Forskerskoles webside, www.dahfo.dk.
19 research students, PhD students and postdocs participated in the meeting, among them Liesbeth Bieghs, Maria Domingo, Steffen Falgreen Larsen, Kim Bergkvist, Thomas Urup, Malene Kjeldsen, Julie Støver Bødker and Maria Bro Kloster from our department. Martin Bøgsted, Mette Nyegaard, Alex Schmitz, Karen Dybkær Sørensen and Hans Erik Johnsen from our department gave lectures.
The annual meeting of Dansk Hæmatologisk Forskerskole will be held again in 2012 same time and place in connection with the annual meeting of Dansk Hæmatologisk Selskab. | | | | 02/02/11 CONCLUSIONS - NMSG WORKSHOP ON TRANSLATIONAL RESEARCH
The NMSG Workshop on "Translational Research in Multiple Myeloma was held at Hotel Hilton Copenhagen Airport the 28th October 2010.
PARTICIPANTS
Lene M Knudsen; Ulf-Henrik Mellqvist; Cecilie Blimark; Ingemar Turesson; Niels Abildgaard; Fredrik Schjesvold; Karen Dybkaer; Peter Gimsing; Anders Waage; Thomas Lund; Markus Hansson; Anette Vangsted; Bjarne Bogen; Einar Haukas; Hans Erik Johnsen; Remes Kari; Anders Sundan.
PROPOSALS
The workshop included presentations and discussions of Nordic translational collaborative trials:
- HGF Intervention trial (Anders Waage)
- Vaccination trial (Bjarne Bogen)
- Genetic polymorphism (Anette Vangsted)
- Relapse trial (Peter Gimsing)
- EMN Chemopredicition Trial synopsis (Karen Dybkær)
- MRD/EMNIT trial synopsis (Hans E Johnsen)
The proposals were presented at the general NMSG meeting Thursday 4th 2010 Copenhagen and it was concluded that the proposals should be discussed and hopefully implemented in 2011.
As per January 2011 we work on the proposals which will be presented as final projects at the upcoming May meeting in Copenhagen.
Ulf-Henrik Mellqvist and Hans E Johnsen
| | | | 24/01/11 Grants received
Mette Nyegaard has received DKK 293,750 from Den Obelske Familiefond based on the project "Undersøgelse af nordjyske kræftpatienter for nyidentificeret arvemasse-mutationer" samt "Nyt gen for hjertearytmi - mutationsundersøgelser af patienter med relaterede hjertelidelser".
Martin Bøgsted has received DKK 90,000 from Den Obelske Familefond based on the project "Validering af en ny test der kan forudsige behandlingsresistens hos knoglemarvskræftpatienter".
Professor Hans E Johnsen has received DKK 375,000 from Den Obelske Familefond based on the project ""Treatment resistance and targeted therapy in myeloma".
Professor Hans E Johnsen has received DKK 125,000 from Spar Nord Fonden based on the project "Treatment resistance and targeted therapy in myeloma".
| | | | 17/01/11 PRIMA study
The Department of Haematology, Aalborg Hospital, has included patients into the PRIMA study just published in the respected journal Lancet Oncology.
The study demonstrated improved progression-free survival in follicular lymphoma patients after Rituximab maintenance treatment. | | | | 16/01/11 New publication in press Paiva B, Pérez-Andrés M, Vídriales M, Almeida J, Heras N, Mateos M, López-Corral L, Gutiérrez NC, Blanco J, Oriol A, Hernández MT, Arriba F, Coca AF, Terol M, Rubia J, González Y, Martín A, Sureda A, Schmidt-Hieber M, Schmitz A, Johnsen HE, Lahuerta JJ, Bladé J, San Miguel JF, Orfao A, on behalf of the GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) cooperative study groups and the Myeloma Stem Cell Network (MSCNET)
"Competition between clonal plasma cells and normal cells for potentially overlapping bone marrow niches is associated with a progressively altered cellular distribution in MGUS vs. myeloma"
The publication has been accepted for publication in Leukemia, december 2010. | | | | 07/01/11 Extension of Grant received Flow Cytometry Core Manager, PhD Alexander Schmitz has been granted an extension of his 1-year “Lars Hvilsted Rasmussen” Post Doc scholarship at Aalborg Hospital Science and Innovation Centre, Aalborg Hospital based on the project "Characterization of normal and malignant cellular subsets in haematopoietic tissue" (Granted Period: 01/05/2011-30/04/2012).
| | | | 07/01/11 Scholarship from "Kræftens Bekæmpelse" Master student in Medical Biotechnology, Annie Bendtsen, has received a scholarship of 100.000 DKK from "Kræftens Bekæmpelse" for the project: "Analysis of Pax5’s promoters and alternative transcripts in diffuse large B-cell lymphoma".
The main objective is to clarify the role of Pax5’s two promoters and resulting alternative transcripts in normal B-cells and in ABC and GCB DLBCL cells.
The aim is to determine the level of expression of the two transcripts of Pax5 by q-PCR and gene expression microarray. To determine the level of the two protein isoforms of Pax5 by Western blot. To determine the methylation level of the promoter sites by methylation sensitive high resolution melting (MS-HRM). To investigate the alternative splicing of Pax5 by exon microarray. | | | | 03/01/11 New publication in press El-Galaly T, Prakash P, Christiansen I, Madsen J, Johansen P, Boegsted M, Johnsen HE and Bukh A
"Efficacy of Routine Surveillance with PET/CT in Aggressive Non-Hodgkin’s Lymphomas in Complete Remission – Status in a Single Center"
The publication has been accepted for publication in Leukemia and Lymphoma. | | | | 27/12/10 New publication in press Van Schijndel JE, Van Zweeden J, Van Loo KMJ, Djurovic S, Andreassen OA, Hansen T, Werge T, Nyegaard M, Sørensen KM, Nordentoft M, Mortensen PB, Mors O, Børglum AD, Del-Favero J, Norrback KF, Adolfsson R, De Hert M, Claes S, Cichon S, Rietschel M, Nöthen MM, Kallunki P, Pedersen JT, Martens GJM.
“Dual association of a TRKA polymorphism with schizophrenia.”
The publication has been accepted for publication in Psychiatric Genetics, 2010. | | | | 15/12/10 Presentations at the 52nd ASH Annual Meeting and Exposition
The Department of Haematology had 2 oral and 2 poster presentations at the 52nd ASH Annual Meeting and Exposition (December 4-7, 2010).
1) Competition Between (Mono)Clonal Plasma Cells and Normal Cells for Potentially Overlapping Bone Marrow Niches Is Associated with a Progressively Altered Cellular Distribution In MGUS Vs. Myeloma. See here.
2) Hypermethylation Is A Key Feature of the Transition of Multiple Myeloma to Plasma Cell Leukemia. See here.
3) Immunophenotypic Analysis of Myeloma Precursors: Antigens for Therapeutic Targeting. See here.
4) Randomized Controlled Trial of Two Different Dosing Regimens of Palifermin to Prevent Mucositis In Multiple Myeloma Patients Receiving One-Day Administration of High-Dose Melphalan. See here. | | | | 12/12/10 Presentation at the European Hematology Association 15th Annual Congress 2010, Barcelona
Gudbrandsdottir S, Frederiksen H, Helleberg I, Jensen B, Kjeldsen L, Klausen T, Larsen H, Mourits-Andersen HT, Nielsen CH, Nielsen OJ, Plesner T, Pulczynski S, Roennow-Jessen D, Hasselbalch HC, Birgens H
"Efficiacy of Rituximab in Combination with Dexamathasone vs Dexamethasone in Newly Diagnosed Patients with Primary Immune Thrombocytopenia – an Interim Analysis of a Prospectibe Randomised Study"
Was presented in the European Hematology Association, at the 15th Annual Congress 2010, Barcelona. See also here.
| | | | 01/12/10 Presentation at the Department of Clinical Genetics
Mette Nyegaard held a presentation entitled "SNP-array-analysis of hydatidiform moles with unusual parental origin of the genome" at the Department of Clinical Genetics, Aalborg Sygehus on November 25th 2010.
| | | | 25/11/10 More than 1500 patients included in the Haematology Biobank As of November the 15th, the Haematology Biobank at Aalborg Hospital has registered more then 1500 patients, with close to 12.000 individual samples. The archived patient material includes blood, plasma, serum and bone marrow samples as well as biopsies. | | | | 25/11/10 Two New PhD Students Steffen Falgreen Larsen and Liesbeth Bieghs have been granted a PhD mobility stipend and are enrolled as PhD students at the Department of Haematology by December 1st 2010.
Steffens PhD project is entitled "Statistical Models Studying Potential Biomarkers for Prediction of Chemotherapy Outcome" and the main supervisor is associate professor Martin Bøgsted, Department of Haematology, Aalborg Hospital, Aarhus University Hospital.
Liesbeths project is entitled "The IGF system in multiple myeloma. Exploring diagnostic and therapeutic potentials" and the main supervisor is associate professor Mette Nyegaard, Department of Haematology, Aalborg Hospital, Aarhus University Hospital. | | | 12/11/10 Roblon Prize Nov 5, 2010 Steffen Falgreen received the Roblon prize for his masters thesis on individualized chemotherapy medication, for more information about the event and the prize see here.
| | | | 04/11/10 New publication Gimsing P, Carlson K, Turesson I, Fayers P, Waage A, Vangsted A, Mylin A, Gluud C, Juliusson G, Gregersen H, Hjorth-Hansen H, Nesthus I, Dahl IM, Westin J, Nielsen JL, Knudsen LM, Ahlberg L, Hjorth M, Abildgaard N, Andersen NF, Linder O, Wisløff F.
"Effect of pamidronate 30 mg versus 90 mg on physical function in patients with newly diagnosed multiple myeloma (Nordic Myeloma Study Group): a double-blind, randomised controlled trial."
In press in the Lancet Oncology, October 2010. See the publication here.
| | | | 04/11/10 Four new publications in press Christensen SK, Glerup S, Raarup MK, Mari MC, Nyegaard M, Koster G, Prabakaran T, Nilsson SK, Kjaergaard MM, Bakke O, Nykjaer A, Olivecrona G, Petersen CM, Nielsen MS. SorLA regulates Lipoprotein Lipase activity by intracellular trafficking.
J Cell Sci. (2010) In press
Petersen M, Andersen JT, Hjelvang BR, Broedbaek K, Afzal S, Nyegaard M, Børglum AD, Stender S, Køber L, Torp-Pedersen C, Poulsen HE. Association of beta-adrenergic receptor polymorphisms and mortality in carvedilol-treated chronic heart failure patients.
Brit J Clin Pharmaco. (2010) In press
Harsløf T, Tofteng CL, Husted LB, Nyegaard M, Børglum AD, Carstens M, Stenkjær L, Brixen K, Eiken K, Jensen JEB, Mosekilde L, Rejnmark L, Langdahl BL. Polymorphisms of the Peroxisome Proliferator-activated Receptor γ (PPARγ) Gene are Associated With Osteoporosis.
Osteoporosis Int. (2010) In press
Harsløf T, Husted LB, Nyegaard M, Carstens M, Stenkjær L, Brixen K, Eiken P, Jensen JEB, Børglum AD, Mosekilde L, Rejnmark L, Langdahl BL. Polymorphisms in the ALOX12 Gene are Associated with Osteoporosis.
Osteoporosis Int. (2010) In press | | | | 04/11/10 European Myeloma Network Flow Cytometry Worskshop, 2010 On the behalf of the European Myeloma Network (EMN), our group together with the group from Alberto Orfao (Salamanca, Spain), have organized a workshop focused on minimal residual disease monitoring in the European Intergroup Trial EMNIT. The workshop was held in Salamanca, Spain on the 23rd of October and ca. 20 scientists from 10 different European countries have participated including Hans E. Johnsen and Alexander Schmitz from our group. The workshop was supported from Cytognos (www.cytognos.com).
More information about the workshop can be found on the EMN homepage (link). | | | | 01/10/10 Oral presentation On 24 September 2010 Alexander Schmitz made an oral presentation of "FACS-SORTED B-CELL SUBPOPULATIONS FROM NORMAL HUMAN SECONDARY LYMPHOID TISSUE; FIVE SUBSETS WITH CONVERGENT GENE EXPRESSION PROFILES AND PHENOTYPE" at the 10th Euroconference on Clinical Cell Analysis in Valencia/Spain, after having been selected for oral presentation from the accepted poster abstracts.
Participation was supported by the Danish Cancer Society (Kræftens Bekæmpelse). 
| | | | 24/09/10 New publication Urup T, Madsen G, Hallager S, Schmitz A, Fogd K, Bøgsted M, Nyegaard M, Sørensen KD, Johnsen HE
"Kræftstamceller i det hæmopoietiske system"
The publication is in press, Ugeskrift for Læger, September 2010. See the publication here. | | | | 24/09/10 New publication in press Paiva B, Pérez-Andrés M, Vídriales MB, Almeida J, de las Heras N, Mateos MV, López-Corral L, Gutiérrez NC, Blanco J, Oriol A, Hernández MT, de Arriba F, de Coca AG, Schmidt-Hieber M, Schmitz A, Johnsen HE, Lahuerta JJ, Bladé J, San Miguel JF and Orfao A on behalf of the GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) cooperative study groups and the Myeloma Stem Cell Network (MSCNET).
“Competition between (mono)clonal plasma cells and normal cells for potentially overlapping bone marrow niches is associated with a progressively altered cellular distribution in MGUS vs. myeloma”
The publication has been accepted for publication in Haematology, 2010. | | | | 23/09/10 New publication Johnsen HE, Hoffmann MH, Klausen TW, Davidsen UH, Bergmann OJ, Boegsted M, Nyegaard M, Bukh A and Dybkaer K
"Health Technology Assessment of Multiplex Reverse Transcriptase- Polymerase Chain Reaction Screening for Translocations at Diagnosis in Acute Myeloid Leukaemia."
The publication has been pressed in European Haematology, 2010. See the publication here. | | | 22/09/10 Conference on Strategic Research Conference on strategic research within cancer treatment Professor Hans E Johnsen from the Department of Haematology, Aalborg Hospital, Aarhus University Hospital, was among the speakers at a conference on strategic research within cancer treatment, bearing the title “Cancer – from treatment of diagnoses to treatment of citizens”
The conference took place on 2 September 2010 at the county hall at Christiansborg and was arranged by the Strategic Research Council (Det Strategiske Forskningsråds programkomiteer for Sundhed, Fødevarer og Velfærd samt for Individ, Sygdom og Samfund)
At the conference leading cancer scientists were telling how they - by means of grants from the Strategic Research Council - research into the individual patient’s specific needs for treatment.
Read programme and see slides from the conference here. | | | 22/09/10 CHEPRE/FoeSU-meeting 12 August The CHEPRE protocol is part of a research co-operation in connection with a grant from the Strategic Research Council, 2007. The latest meeting was held on 12 August 2010. | | | | 12/09/10 New publication in press
Pilgaard L, Højfeldt AD, Lundby L, Dybkær K, Hokland P, Johnsen HE
"Den hæmatologiske biobank er en infrastruktur til kvalitetssikring, udvikling og forskning"
The publication has been accepted for publication in Ugeskrift for Læger, 2010. | | | | 09/09/10 Participation in the AMEE conference 2010 Simon Mylius has participated in the AMEE conference (Association for Medical Education in Europe) from 4 to 8 September.
AMEE is a worldwide organization with members in 90 countries. The conference was held in Glasgow, Scotland, and lasted 5 days with courses, workshops, symposiums, poster sessions and more, discussing the actual and future perspectives of medical education in global and local settings. Simon participated as a representative from the Medical Students Association at Aarhus University.
Participation was supported by the Faculty of Health Sciences at Aarhus University.
| | | | 06/09/10 New publication Engelhardt M, Udi J, Kleber M, Spencer A, Rocci A, Knop S, Bruno B, Bringhen S, Pérez-Simón JA, Zweegman S, Driessen C, Patriarca F, Gramatzki M, Terpos E, Sezer O, Kropff M, Straka C, Johnsen HE, Waage A, Boegsted M, Lokhorst H, Hájek R, Morgan G, Boccadoro M, Ludwig H, Cavo M, Polliack A, Sonneveld P, Einsele H, Palumbo A.
"European Myeloma Network: the 3rd Trialist Forum Consensus Statement from the European experts meeting on multiple myeloma."
The publication has been accepted for publication in Leukemia and Lymphoma. 2010 August 31. See the publication here. |
| | 01/09/10 New publication Laursen MB, Pakula MM, Gao S, Fluiter K, Mook OR, Baas F, Langklaer N, Wengel SL, Wengel J, Kjems J, Bramsen JB.
"Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo."
The publication has been accepted for publication in Molecular BioSystem, 2010. See the publication here.
| | | | 25/08/10 New publication in press
Donk NWCJ, Lokhorst HM, Dimopoulos M, Cavo M, Morgan G, Einsele H, Kropff M, Schey S, Avet-Loiseau H, Ludwig H, Goldschmidt H, Sonneveld P, Johnsen HE, Bladé J, San-Miguel JF, Palumbo A on behalf of the European Myeloma Network
"Treatment of Relapsed and Refractory Multiple Myeloma in the Era of Novel Agents"
The publication has been accepted for publication in Cancer treatment reviews, 2010. | | | | 24/08/10 New Master students
Sophie Bech Rasmussen, Annie Bendtsen, and Hanne Munkøe have started their master thesis August 2010. They have all a background in Biotechnology.
The titles of their projects are: Cytogenetic profiling of B cell lymphomas (Sophie), Analysis of PAX5 promoter and alternative transcripts in diffuse large B cell lymphoma (Annie), and Identification of specific miRNAs in B cell subpopulations (Hanne). | | | | 24/08/10 New publication in press
Pérez-Andres M, Paiva B, Nieto WG, Caraux A, Schmitdz A, Almeida J, Vogt R, Rawstron AC, Martin G, Johnsen HE, Klein B, Orfao A
"Human peripheral blood B-cell compartments: a cross in B-cell traffic"
The publication has been accepted for publication in Clinical Cytometry 2010. | | | | 19/08/10 New publication in press
Brimnes MK, Vangsted AJ, Knudsen LM, Gimsing P, Gang AO, Johnsen HE, Svane IM.
"Increased level of both CD4+FOXP3+ regulatory T cells and CD14+HLA-DR-/low myeloid derived suppressor cells and decreased level of dendritic cells in multiple myeloma patients"
The publication has been accepted for publication in Scandinavian Journal of Immunology. | | | | 09/08/10 New publication in press
Thomassen SA, Larsson A, Andreasen JJ, Bundgaard W, Boegsted M, Rasmussen BS
"Should blood flow during cardiopulmonary bypass be individualized more than to body surface area"
The publication has been accepted for publication in Perfusion. | | | | 11/07/10 New publication Boegsted M, Rasmussen JG and Schwefel HP.
"Connectivity analysis of one-dimensional ad-hoc networks"
The publication has been accepted for publication in Wireless Networks. | | | | 03/07/10 New publication Hoejfeldt AD, Johnsen HE, Boegsted M, Fogd K, Pilgaard L, Nyegaard M, Dybkaer K, Bukh A.
"Brug af en translationel database i en klinisk afdeling."
Ugeskrift for Læger. July 2010 | | | | 03/07/10 New publication in press
Prolonged hypoxic culture and trypsinization increase the proangiogenic potential of human adipose tissue-derived stem cells
Jeppe Grøndahl Rasmussen, MD 1, 2, Ole Frøbert, MD, PhD 3, Linda Pilgaard, Cand. polyt., PhD 2, 4, Jens Kastrup, MD, DMSci 5, Ulf Simonsen, MD, PhD 1, Vladimir Zachar, MD, PhD 2, Trine Fink, Cand. scient., PhD 2
1 Department of Pharmacology, Aarhus University, Denmark, 2 Laboratory for Stem Cell Research, Aalborg University, Denmark, 3 Department of Cardiology, Örebro University Hospital, Sweden, 4 Aalborg Hospital Science and Innovation Center
| | | | 02/07/10 Grant received Professor Hans E Johnsen has received DKK 300,000 from Det Obelske Familiefond based on the project "Improving chemosensitivity prediction for acute myeloid leukemia"
| | | | 02/07/10 Grant received Professor Hans E Johnsen has received DKK 1,000,000 from Karen Elise Jensen Fonden based on the project "Improving chemosensitivity prediction for acute myeloid leukemia" | | | | 24/06/10 Nanocarrier and Viral Delivery of Gene Silencing Therapeutics Alex Schmitz has given a lecture (22/06/2010) in Aarhus within a PhD course. Course title: "Nanocarrier and Viral Delivery of Gene Silencing Therapeutics".
iNANO School PhD Course N11; 21st – 25th June 2010 Organized by the Interdisciplinary Nanoscience Center, Aarhus University, Denmark.
The title of the talk was "Introduction into Flow Cytometry".
Duration: 1 hour. | | | | 22/06/10 Partek Genomics Suite training course Maria B. Kloster, Maria Bach Laursen, Charlotte Mandrup Ozimek and Kim S. Bergkvist have participated in the Partek Genomics Suite training course at Copenhagen University Hospital on the 16-18 June 2010.
| | | | 13/06/10 New Employee at the Haematology Biobank The internship that was granted to Stig Castberg has been extended to public wage subsidy, which is a part-time position at the Haematology Biobank.
Stig graduated in 2009 from the Institute of Physics and Nanotechnology at Aalborg University. His master was on the subject 'Expression of an Indolicidin Analogue in the Yeast Pichia Pastoris'. During his education he has obtained laboratory experience with bacteria and yeast cells as well as different peptides and proteins.
Stig will be preparing the daily samples of the Biobank.
| | | | 01/06/10 Single Cell Analysis PhD student Kim Steve Bergkvist has been attending the “Single Cell Analysis Congress” in Dublin, Ireland.
http://www.selectbiosciences.com/conferences/SCAC2010/index.aspx | | | | 28/05/10 Acute Myeloid Leukemia – disease mechanisms, animal models and novel therapies Maria B. Kloster, Torben L. Andersson, Kim S. Bergkvist and Charlotte Mandrup Ozimek have participated in the PhD course entitled "Acute Myeloid Leukemia – disease mechanisms, animal models and novel therapies". The PhD course took place at the Biotech Research & Innovation Centre in Copenhagen on 17-21 May 2010. | | | | 28/05/10 Microsymposium on small RNAs Maria Bach Laursen has participated in the Microsymposium on small RNAs. The symposium took place at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences in Vienna on 17-19 May 2010.
| | | | 26/05/10 New publication Rasmussen T, Haaber J, Dahl IM, Knudsen LM, Kerndrup GB, Lodahl M, Johnsen HE and Kuehl M.
"Identification of translocation products but not K-Ras mutations in memory B cells from multiple myeloma patients."
The publication has been accepted for publication in Haematologica.
This report indicates that the clonotypic memory myeloma B cells most likely is a reminiscence of a premalignant compartment - not involved in disease progression. | | | | 20/05/10 New publication with Mette Nyegaard as co-author Transgenic Overexpression of Pregnancy-Associated Plasma Protein-A in Murine Arterial Smooth Muscle Accelerates Atherosclerotic lesion Development.
Conover CA, Mason MA, Bale LK, Harrington SC, Nyegaard M, Oxvig C, Overgaard MT.
Am J Physiol Heart Circ Physiol (in press). See the publication here.
| | | | 20/05/10 Presentation Today Anders Petersen will present his project with the title: "Distinct expression of mir-143 and mir-145 in patients with and without extranodal sites in Diffuse Large B-Cell Lymphoma" at the 14th Plenary meeting in the Danish Lymphoma Group. The meeting will be held at Vejle Hospital. | | | | 11/05/10 New publication Fogd K, Hansen SM, Madsen LH, Kjeldsen MK, Johnsen HE
"The Cancer Stem Cell Concept in Multiple Myeloma - From Phenomenology to Characterisation."
European Haematology, vol. 4 p94-95, Touch Briefings, London. | | | | 11/05/10 New publication Hydroxyurea has been used for treatment of blood cancers since the early nineteen-sixties. We have now identified the hydrogen peroxide decomposing enzyme catalase as a novel direct and biologically significant target of hydroxyurea.
Publication details:
“The in vivo toxicity of hydroxyurea depends on its direct target catalase”
Trine Juul, Anna Malolepszy, Karen Dybkær, Rune Kidmose, Jan Trige Rasmussen, Gregers Rom Andersen, Hans Erik Johnsen, Jan-Elo Jørgensen and Stig Uggerhøj Andersen.
The paper in press is available at the JBC wesite:
http://www.jbc.org/content/early/2010/05/07/jbc.M110.103564.abstract
| | | | 04/05/10 Participation in seminar
Louise Madsen, Ann-Maria Jensen and Helle Høholt are participating in the seminar "Celleforsknings Seminar" at Aarhus University on 4 May 2010. The company Fisher Scientific holds the seminar.
| | | | 27/04/10 More than 1200 patients included in the Haematology Biobank As of April 26th, more than 1200 patients are registered in the Haematology Biobank at Aalborg Hospital. The archived patient material includes blood, plasma, serum and bone marrow samples as well as biopsies. In total, the Haematology Biobank holds close to 10.000 individual sample vials. | | | | 26/04/10 Participation in the Blood and Biomarker meeting Torben L. Andersson, Charlotte Mandrup Ozimek, Maria Bach Laursen, Maria Bro Kloster and Kim Steve Bergkvist have participated in the meeting "Blood and Biomarkers" held by The Danish Society for Biochemistry and Molecular Biology (Biokemisk Forening) on 20 April 2010 at The Utzon Center, Aalborg. | | | | 25/04/10 New publication with Mette Nyegaard as co-author Buttenchøn, Henriette Nørmølle; Foldager, Leslie; Flint, Tracey J.; Olsen, Inger Marie L.; Deleuran, Thomas; Nyegaard, Mette; Hansen, Mette M.; Kallunki, Pekka; Christensen, Kenneth V.; Blackwood, Douglas H.; Muir, Walter J.; Straarup, Steen E.; Als, Thomas D.; Nordentoft, Merete; Børglum, Anders D.; Mors, Ole
"Support for a bipolar affective disorder susceptibility locus on chromosome 12q24.3" The publication is in press in Psychiatric Genetics
| | | | 20/04/10 Master thesis by Steffen Falgreen Larsen on 24 June 2010 Master student, Steffen Falgreen Larsen, will defend his master thesis on Thursday 24 June at 11.00 a.m. in the lecture room (Auditoriet), Forskningens Hus. The thesis is entitled: "Methods for selecting chemoresistance marker genes"
Supervisor: Martin Bøgsted
External examiner: Professor Torben Martinussen, Forskningsenheden for Biostatistik, Syddansk Universitet | | | | 19/04/10 New Intern at the Haematology Biobank On Monday 12 April Stig Castberg, the newly graduated bio-engineer, started a four week internship at the Haematology Biobank.
Stig graduated in 2009 from Institute of Physics and Nanotechnology at Aalborg University. His master was on the subject 'Expression of an Indolicidin Analogue in the Yeast Pichia Pastoris'. During his education he has worked in the laboratory with both bacteria and yeast cells and different peptides and proteins.
During his internship, Stig will be introduced to the daily routine of the Biobank by Biobank Manager, Linda Pilgaard.
| | | | 17/04/10 Participation in DAFKO's Annual Meeting and the Haematological Spring Meeting. Anders Petersen, Torben L. Andersson, Maria Bach Laursen, Maria Bro Kloster and Kim Steve Bergkvist have participated in DAFKO's Annual Meeting in Vejle on 14 and 15 April and the Haematological Spring Meeting in Århus on 15 April. | | | | 15/04/10 Joint Haematological Spring Meeting 2010 for the North and Central region of Denmark The time has come for the joint annual spring meeting for the Department of Haematology at Aarhus and Aalborg Hospital. Here all aspects of Haematology are linked together – clinical and basic research, diagnostics and nursing. Program (in Danish) | | | | 25/03/10 New publication Kjeldsen MK, Dybkaer K, Liu J, Pedersen FS.
"BACH2 (BTB and CNC homology 1, basic leucine zipper transcription factor 2)."
Atlas Genet Cytogenet Oncol Haematol. January 2010. See also: Atlas of Genetics and Cytogenetics in Oncology and Haematology. | | | | 24/03/10 Grant received
Bioengineer, PhD Linda Pilgaard has been granted a 1-year Post Doc scholarship at Aalborg Hospital Science and Innovation Centre, Aalborg Hospital based on the project “The cellular and molecular characterization of dual genetic classes of multiple myeloma”.
| | | | 24/03/10 New PhD student
Kim Steve Bergkvist has been registered as PhD student at The University of Aarhus Graduate School of Health Sciences, 1 March 2010 with the project:
"STUDIES OF SMALL DISCRETE POPULATIONS OF B CELLS BY MICROARRAY TECHNOLOGY"
- In search of cancer stem cell associated genes in multiple myeloma. | | | | 23/03/10 Cytogenetics Research Solution Training course Our bioanalysts Helle Hoeholt, Ann-Maria Jensen and Louise Hvilshoej Madsen have attended a Cytogenetics Research Solution Training course on 2-4 March 2010. Juan Cuevas, a field and applications specialist from Affymetrix, was responsible for the training. The course was held in AHSIC-Aalborg Hospital Science and Innovation Center.
| | | | 23/03/10 Seminar on cancer stem cells and biobanking On Friday March 19th Post Doc, Kirsten Fogd gave a seminar on strategies in the identification and characterization of cancer stem cells in haematology. This was followed by Post Doc, Linda Pilgaard with a seminar on biobanking and a tour of the Haematology Biobank at Aalborg Hospital. Approximately 20 students from Industrial Medicine at Aalborg University participated in the event. | | | | 23/03/10 New publication Johnsen HE, Tobias W Klausen, Martin Boegsted, Stig Lenhoff, Peter Gimsing, Ilse Christiansen, Tobias Gedde-Dahl, Roald Lindås and Ulf-Henrik Mellqvist on behalf of the Nordic Myeloma Study Group (NMSG).
"Improved survival for multiple myeloma in Denmark based on autologous stem cell transplantation and novel drug therapy in collaborative trials - Analysis of accrual, prognostic variables, selection bias and clinical behaviour on survival in more than 1200 patients in trials of the Nordic Myeloma Study Group."
Leukemia, Lymphoma and Myeloma, In Press March 2010
| | | | 17/03/10 Grant received Associate Professor Karen Dybkær has received DKK 50.000 kr from AUFF (Aarhus University Research Fund) based on the project " Prediction of chemosensitivity in B cell malignancies"
| | | | 13/03/10 New publication in press The manuscript
"Multiparametric Flow Cytometry Profiling of Neoplastic Plasma Cells in Multiple Myeloma"
Hans E Johnsen (1,2), Martin Bøgsted (1), Tobias W Klausen (2), Peter Gimsing (3), Alexander Schmitz (1), Erik Kjærsgaard (2), Tina
Damgaard (2), Pia Voss (2), Lene M Knudsen (2,4), Anne K Mylin (2,3), Johan Lanng Nielsen (5), Bo Björkstrand (6), Gruber Astrid (7), Stig Lenhoff (8), Kari Remes (9), Inger Marie Dahl (10), Kirsten Fogd (1) and Karen Dybkær (1) on behalf of the Nordic Myeloma Study Group (NMSG) and the Myeloma Stem Cell Network (MSCNET).
Department of Haematology, Medical Center and Aalborg Hospital Science and Innovation Center (AHSIC), Aarhus University Hospital (1), Herlev University Hospital (2), Rigshospitalet (3), Odense University Hospital (4), Aarhus Hospital Aarhus University Hospital (5), Denmark; Huddinge University Hospital (6), Karolinska University Hospital Solna, Stockholm (7), Lund University Hospital, Lund, Sweden (8); University Central Hospital, Turku, Finland (9); Tromsoe University Hospital, Norway (10)
has been accepted for publication in Cytometry: Part B - Clinical Cytometry in press. | | | | 10/03/10 In Press 9.3.2010 BMT
"Priming with r-metHuSCF and Filgrastim or Chemotherapy and Filgrastim in Patients with Malignant Lymphomas
A randomized phase II pilot study of Mobilization and Engraftment"
Johnsen Hans Erik1,2, Geisler Christian3, Juvonen Eva4, Remes Kari5, Juliusson Gunnar6, Hornsten Per7, Kvalø Stein8, Kvalheim Gunnar8, Jürgensen Gitte W1, Pedersen Lars Moeller1, Bergmann Olav Janus1, Alexander Schmitz2 and Boegsted Martin2
Aalborg Hospital, Aarhus University Hospital, Denmark1, Herlev University Hospital, Copenhagen Denmark2 , Rigshospitalet, Copenhagen Denmark3, University Hospital, Helsinki Finland4, University Hospital Turku Finland5, University Hospital, Linköping Sweden6 University Hospital, Umeå Sweden7, Radiumhospitalet, Oslo Norway8 | | | | 10/03/10 Job vacancy- statistician
A position as statistician is available at the Research Department of Haematology, Aalborg Hospital, read more (in Danish) | | | | 10/03/10 Blood and Biomarkers
The Danish Society for Biochemistry and Molecular Biology (Biokemisk Forening) holds a meeting with the title "Blood and Biomarkers" on 20 April 2010 at The Utzon Center, Aalborg.
Registration and programme can be found at http://www.biokemi.org/meetings/44 | | | | 10/03/10 The National Medical Student Research Congress 5–7 March 2010
Simon Mylius participated in the National Medical Student Research Congress which was held at Sandbjerg Gods in the South of Jutland, Denmark, from 5-7 March 2010.
At the Congress more than 80 medical students presented their scientific work. There were 7 oral sessions and many posters, all in English.
The research projects consisted among others of epidemiological, neurological, cardiological and immunological projects.
As Simon Mylius had arranged the congress together with the other board members of the Society of Medical Research Students he participated in the congress.
The congress was a success.
| | | 16/02/10 Defense of scientific methodology assignment
Johanne Marie Holst defended her scientific methodology assignment, Thursday, 16th of January. Her project is entitled "Treatment Prediction of Melphalan Therapy using Dose Response Experiments, Gene Expression profiles and Multivariate Regression Analysis". 
| | | 16/02/10 SUMA-9 project defense
Steffen Falgreen Larsen defended his SUMA-9 project Tuesday, 26th of January, 2010. His project is entitled "Chemoresistance -- Nonlinear mixed effects modelling of chemoresistance in human tumour cell lines", and concerns estimation of melphalan resistance of multiple myeloma cell lines. 
| | | 16/02/10 Status meeting
The Chepre/FøSu status meeting was held on Friday the 12. of February at "Mødelokale 9.2 Medicinerhuset ".
See the agenda (in danish) here.
| | | 06/02/10 New publication
New publication with Mette Nyegaard as first author:
Lack of Functional Pregnancy-Associated Plasma Protein-A (PAPPA) Compromises Mouse Ovarian Steroidogenesis and Female Fertility
Nyegaard M, Overgaard MT, Su Y, Hamilton AE, Kwintkiewicz J, Hsieh M, Nayak NR, Conti M, Concover CA and Giudice LC
The publication has been published in Biology of Reproduction. 2010 Feb 10. See the publication here. | | | 05/02/10 Scientific Seminar 1.2.2010
Our collaborator Cand Scient PhD Stig U. Andersen from the Department of Molecular Biology, University of Aarhus presented data on "A novel direct target of hydroxyurea - identification and clinical investigation" Abstract: The Hydroxyurea has a cytoreductive effect that is beneficial in a number of hematological malignancies, but many of these eventually develop hydroxyurea resistance. To address this issue, a plant model system was used to identify genetic lesions resulting in hydroxyurea resistance and a gene product, which directly interacts with and is inhibited by hydroxyurea, was identified. The clinical significance of this interaction is now being investigated both retrospectively and prospectively in a collaboration between the Department of Hematology, Aalborg Hospital and the Department of Molecular Biology, Aarhus University with the aim of developing new prognostic tools to guide clinical decisions in individual cases. | | | 25/01/10 New publication
New publication with Mette Nyegaard as first author: CACNA1C (rs1006737) is associated with schizophrenia
Nyegaard M, Demontis D, Foldager L, Hedemand A, Flint TJ, Sørensen KM, Andersen PS, Nordentoft M, Werge T, Pedersen CB, Hougaard DM, Mortensen PB, Mors O and Børglum AD
The publication has been published in Molecular Psychiatry. 2010 Feb 10. See the publication here. | | | 25/01/10 New publication
New publication with Karen Dybkær as co-author: Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma.
Iqbal J, Weisenburger DD, Greiner TC, Vose JM, McKeithan T, Kucuk C, Geng H, Deffenbacher K, Smith L, Dybkaer K, Nakamura S, Seto M, Delabie J, Berger F, Loong F, Au WY, Ko YH, Sng I, Armitage JO, Chan WC.
The publication has been published in Blood. 2010 Feb 4. See the publication here. | | | 18/01/10 New presentation
On 15.01.2010 Maria Bro Kloster presented a poster at the PhD day Faculty of Health Sciences Aarhus University:
The role of BCL6 and PRDM1 promoters and isoforms in B cell differentiation and malignancies. See the presentation here. | | | 18/01/10 New presentation
On 15.01.2010 Torben L. Andersson presented a poster at the PhD day Faculty of Health Sciences Aarhus University:
Protein Profiles of Chemoresistance in B-cell Malignancies studied in Myeloma Cell Lines and the Myeloma Hierarchy by Protein Array Analysis.
See the presentation here. | | | 18/01/10 New presentation
On 15.01.2010 Malene Krag Kjeldsen presented a poster at the PhD day Faculty of Health Sciences Aarhus University:
SOX4 in malignant lymphopoiesis
She won the poster prize in her group. See the presentation here. | | | 18/01/10 New presentation
On 15.01.2010 Anders Petersen presented a poster at the PhD day Faculty of Health Sciences Aarhus University:
Nodal and extranodal manifestations of Diffuse Large B-Cell Lymphoma differ in expression of specific microRNAs. See the presentation here. | | | 14/01/10 New publication
Mette Nyegaard is co-author of a new publication: Expanding the range of ZNF804A variants conferring risk of psychosis.
Steinberg S, Mors O, Børglum AD, Gustafsson O, Werge T, Mortensen PB, Andreassen OA, Sigurdsson E, Thorgeirsson TE, Böttcher Y, Olason P, Ophoff RA, Cichon S, Gudjonsdottir IH, Pietiläinen OPH, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Athanasiu L, Suvisaari J, Lonnqvist J, Paunio T, Hartmann A, Jürgens G, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Breuer R, Möller H-J, Giegling I, Glenthøj B, Rasmussen HB, Mattheisen M, Bitter I, Réthelyi JM, Sigmundsson T, Fossdal R, Thorsteinsdottir U, Ruggeri M, Tosato S, Strengman E, GROUP, Kiemeney LA, Melle I, Djurovic A, Abramova L, Kaleda V, Walshe M, Bramon W, Vassos W, Li T, Fraser G, Walker N, Toulopoulou T, Yoon J, Freimer NB, Cantor, Murray R, Kong A, Golimbet V, Jönsson EG, Terenius L, Agartz I, Petursson H, Nöthen MN, Rietschel M, Peltonen L, Rujescu D, Collier DA, Stefansson H, St Clair D and Stefansson K
The publication has been published in Molecular Psychiatry. 2010 Jan 5. See the publication here. | | | 08/01/10 Highlights from 2009
Another year has passed with a lot of activities and important changes.
Most importantly, the head of our research laboratory Cand Scient PhD Karen Dybkaer obtained a position as Associate Professor at Aarhus University, Clinical Institute.
Cand Scient PhD Mette Nyegaard has been employed as a senior scientist in molecular genetics and Cand Scient PhD Alexander Schmitz has been employed as our new full time Flow Cytometry and Sorting Manager.
Medical student Johanne Marie Holst and Stud stat Steffen Falgreen Larsen were employed part time in our statistical unit, supervised by Martin Boegsted.
Kirsten Fogd and Linda Piilgaard received their PhD from Aalborg University. Emilie Kallehauge finished her master thesis.
The technicians Hanne T. Larsen, Rikke Barsdal and Helle Høholt and the scientists Alex Schmitz, Linda Pilgaard and Kirsten Fogd visited the “Banco Nacional de ADN” and the Flow Core Unit at the University of Salamanca.
Research Assistants
In 2009 the Research Laboratory was assisted by four medical research assistants to contribute to the ongoing research. All projects made use of Affymetrix gene expression data as well as B-cell differentiation.
Jakob Virenfeldt focused on haematopoietic differentiation and their involvement in lymphoma genesis.
Katrine Gade worked with characterization of B-cell markers by flow cytometry and gene expression analysis of haematopoietic cell lines.
Sofie Hallager worked with analyzing and comparing gene expression in embryonic stem cells, B-cell lines, normal B-cells and normal tissue cells.
Jonas Svenningsen worked with identification of disease specific genes in haematological cancers by in silico analysis with the corresponding cell lines.
Scientific Seminar
Martin Perez-Andres stayed at the Research Laboratory for 3 months (from October to December) as a guest researcher. Martin holds a PhD in Haematology from the University of Salamanca (Spain) focused on Multiple Myeloma interaction with the immunological bone marrow microenvironment.
Martin worked in a joint-project on identification, isolation and characterization of the B cell subsets in normal individuals and patients suffering from malignant B cell diseases.
In November Martin held a presentation with the title "Immunophenotyping of haematological malignancies: Application for diagnosis and monitoring in multiple Myeloma”.
He is now back in Spain, working as Assistant Professor of Immunology at the Department of Medicine, University of Salamanca. He is interested in B-cells biology both in normal and pathological conditions.
FøSu Meeting, summer 2009
The half-yearly FøSu meeting was held in august 2009.
At the meeting the work packages 1-6 were discussed:
Work package 1:
This work package will probably result in 10-20 publications.
Work package 2:
Phase III clinical trial: A prospective randomized trial of second line therapy in lymphoma patients comparing outcome of conventional with individual DNA chip predicted experimental chemotherapy CHEPRE now includes all haematological diseases and the revised protocol has been implemented. There will be a status check when 50 patients have been implemented.
There will be a new protocol that includes Diffuse Large B-cell recidives and professor Hans Erik Johnsen is in contact with multiple centers which might be interested in international European protocol cooperation.
Steen Knudsen presented prediction on blinded retrospective Diffuse Large B-Cell samples and scheduled the next 6 months.
Work Package 3:
Malene Krag and Alex Schmitz presented FACS results from sub-population prediction and tonsil samples.
Work Package 4:
Karen Dybkaer suggested a new definition of WP4 and this was discussed.
Work Package 5 and 6:
Finn Skou Pedersen presented background, results and status. Nearly all mice have developed symptoms. A comparison between human and murine results was presented. 
Summer trip to Egholm
This year’s summer trip went to Egholm and everybody enjoyed the day.
Everybody at the Research Laboratory look forward to 2010. | | | 31/12/09 Two publications in press "Circulating human B and plasma cells. Age-associated changes in counts and detailed characterization of circulating normal CD138- and CD138+ plasma cells"
Anouk Caraux, Bernard Klein, Bruno Paiva, Caroline Bret, Alexander Schmitz, Gwenny M. Fuhler, Nico A. Bos, Hans E Johnsen, Alberto Orfao, and Martin Perez-Andres for the Myeloma Stem Cell Network (MSCNET)
In Press in Haematologica 2009
"Den kliniske forskningsenhed"
In Press in Ugeskrift for Læger 2009 | | | 12/12/09 Congress of Medical Student Research The society for Medical Student Research has announced that registration to next year's Congress of Medical Student Research
5-7 March 2010 is now open.
Simon Mylius is a board member of the society and has together with other board members assisted in raising funds for the congress.
Simon Mylius will be attending the meeting. | | | 8/12/09 Merry Christmas and a Happy New Year!  | | | 24/11/09 Scientific Seminar Place: Medicinerhuset, Department of Haematology, Aalborg Hospital;
Time: 30th of November 2009 at 13.30-14.30.
Speaker: Martin Perez-Andres who is Assistant Professor of Immunology at the Department of Medicine, University of Salamanca, Spain.
Title:"Immunophenotyping of hematological malignancies: application for diagnosis and monitoring in multiple myeloma".
| | | 24/11/09 Coauthorship at two oral presentations At the upcoming ASH meeting in New Orleans in December 2009 the department of haematology is coauthor at two oral presentations:
1. “Febrile Neutropenia Risk Assessment and Granulocyte-Colony Stimulating Factor Support in Patients with Diffuse Large B Cell Lymphoma Receiving R-CHOP Regimens”
This takes place on Sunday December 6, 2009 at 5.30 p.m. at R02-R05 (Ernest N. Morial Convention Center)
2. “Clinical Impact of TP53 Gene Mutations in Diffuse Large B-Cell Lymphoma (DLBCL): An International DLBCL Rituxan-CHOP Consortium Program Study”
This presentation takes place on Tuesday December 8, 2009, at 7.30 a.m. at E-1 (Ernest N. Morial Convention Center)
| | | 24/11/09 "New" staff member
Alexander Schmitz is a new staff member as of 1 January 2010. Alex holds a doctoral degree in natural science (dr.rer.nat) from Giessen University (Germany). He did a post doc at the molecular biology department (MBI), Aarhus University. Since 2002 Alex has been responsible for the establishment, management and operation of the flow cytometry unit (FCU) at MBI.
In 2007 he started working part-time at Aalborg Hospital Science and Innovation Centre (AHSIC) to establish a core function for flow cytometry and cell sorting at the Research Laboratory at the Department of Haematology, Aalborg Hospital, Aarhus University.
Alexander Schmitz will continue this work, now employed full-time as cell sorting and flow cytometry manager, providing technical and application support and expert advice, as well as holding the overall responsibility for the day-to-day running and maintenance of the flow
analysers (BD FACSCanto2) and cell sorters (BD FACSAriaI). | | | 24/10/09 Research nurse
The joint unit of clinical cancer research has announced a job opportunity for a research nurse.
Please read the announcement and job description here (in Danish). | | | 13/10/09 Guest researcher Martin Perez-Andres is staying at the Research Laboratory for 3 months as a guest researcher, starting from October 5th 2009. Martin holds a PhD in Haematology from University of Salamanca (Spain) focussed on Multiple Myeloma interaction with the immunological bone marrow microenvironment. Nowadays, he is working as Assistant Professor of Immunology at the Department of Medicine, University of Salamanca (Spain) and he is interested in B-cells biology both in normal and pathological conditions. Martin will be working in a joint-project on identification, isolation and characterization of the B cell subsets in normal individuals and patients suffering from malignant B cell diseases (Link to CV). | | | 05/10/09 ESMO/ECCO Congress in Berlin 2009 Professor Hans E Johnsen was invited as a speaker for the ESMO/ECCO Congress Berlin 2009.
In the educational session "All you wanted to know about cancer stem cells but were afraid to ask" he presented the presentation entitled: "Cancer stem cells and the cellular hierarchy in haematological malignancies". See the presentation here. | | | 05/10/09 New publication Up-front fludarabine impairs stem cell harvest in multiple myeloma: report from an interim analysis of the NMSG 13/03 randomized placebo controlled phase II trial. Johnsen HE, Knudsen LM, Mylin AK, Gimsing P, Gregersen H, Abildgaard N, Andersen NF, Plesner T, Vangsted A, Mourits-Andersen T.
The publication has been published in Hematology Reviews 2009; Vol 1, No 2. See the publication here. | | | 05/10/09 New publication Cancer stem cells and the cellular hierarchy in haematological malignancies. Johnsen HE, Kjeldsen MK, Urup T, Fogd K, Pilgaard L, Boegsted M, Nyegaard M, Christiansen I, Bukh A, Dybkaer K.
The publication has been published in European Journal of Cancer. 2009 Sep;45 Suppl 1:194-201. See the publication here. | | | 02/10/09 Statistical analysis course Martin Bøgsted has attended the course 'Statistical analysis of gene expression data with R and Bioconductor', August 17-21, 2009, Copenhagen, Denmark.
| | | 28/09/09 New staff member Mette Nyegaard is a new staff member as of June 1st 2009. Mette holds a PhD in Medical Genetics from Odense University, did a postdoc at Stanford Univerisity Medical School and comes from a position as Assistant Professor at the Department of Human Genetics, Århus University. Mettes special interest is genetic variation in human diseases. Mette is employed as a senior scientist and will be focusing on identifying somatically acquired mutations and genes critical for the development of human cancers. | | | 26/09/09 New publication
Further immunohistochemical characterization of BRD1 a new susceptibility gene for schizophrenia and bipolar affective disorder.
Bjarkam CR, Corydon TJ, Olsen IM, Pallesen J, Nyegaard M, Fryland T, Mors O, Børglum AD.
The publication has been published in Brain Struct Funct. 2009 Sep 10. See the publication here. | | | 22/09/09 qPCR course 10th and 11th of september 2009, PhD student Maria Bro Kloster and PhD student Malene Krag Kjeldsen attended the Biogazelle course on qPCR in Gent, Belgium. | | | 20/09/09 New publication
Martin Bøgsted is co-author of a new publication:
Probabilistic models for access strategies to dynamic information elements
Martin Bøgsted, Rasmus L. Olsen and Hans-Peter Schwefel The publication has been published in Performance Evaluation, September, 2009 See the publication here. | | | | 07/09/09 In house Affymetrix Cytogenetics SNP6 training
We are implementing SNP analysis at the research laboratory. In connection to this a technical expert from Affymetrix is giving a 4 days crash course for interested staff in the method involving hands-on experience with the method as well as insights into data analysis and interpretation. See the program here. | | | 06/09/09 New publication
Mette Nyegaard is first-authors of a new publication:
Support of association between BRD1 and both schizophrenia and bipolar affective disorder
Nyegaard M, Severinsen JE, Als TD, Hedemand A, Straarup S, Nordentoft M, McQuillin A, Bass N, Lawrence J, Thirumalai S, Pereira AC, Kandaswamy R, Lydall GJ, Sklar P, Scolnick E, Purcell S, Curtis D, Gurling HM, Mortensen PB, Mors O, Børglum AD. The publication has been published in American Journal Medical Genetics Part B Neuropsychiatric Genetics, August, 2009 See the publication here.
| | | | 31/08/09 Autumn meeting at the Department of Haematology
The time has come for the annual autumn meeting at the Department of Haematology, linking all aspects of Haematology together – clinical and basic research, diagnostics and nursing. This year the 3 main topics are:
1) Interaction between oncology and haematology
2) Oral care of patients
3) The Biobank – what “interests” does it pay?
The meeting is sponsored by Roche. Link to program (in Danish)
| | | | 17/08/09 Status meeting Chepre/FøSu status meeting on Friday 21 August at "Mødelokale 9.2 Medicinerhuset ".
The agenda has been forwarded to invited participants. See the agende (in danish) here. | | | | 17/08/09 New master student Steffen Falgreen Larsen will be starting his master thesis entitled "Cell line models for chemoresistance" September 1st. Steffen has a background in Statistics and is a familiar face in the department as he has been employed previously as student worker.
| | | | 17/08/09 New research assistant Johanne Marie Holst, medical student, has been employed as research assistant with the project entitled: "Predictors of melphalan chemosensitivity in multiple myeloma". | | | | 17/08/09 New master student 
Alice Østergaard has started her master thesis entitled: '' SOX4' rolle i differentiering og maligne B-celle tilstande'' (The role of SOX4 in differentiation and maligant B-cell disorders). She has a background in Biotechnology. | | | | 07/07/09 New publication
Linda Pilgaard is first-authors of a new publication: Effect of oxygen concentration, culture format and donor variability on in vitro chondrogenesis of human adipose tissue-derived stem cells.
L Pilgaard1,2, P Lund1, M Duroux1, T Fink1, M Ulrich-Vinther3, K Søballe3 & V Zachar1 1 Laboratory for Stem Cell Research, Aalborg University, Fredrik Bajers Vej 3B, 9220 Aalborg, Denmark.
2 Aalborg Hospital Science and Innovation Center, Department of Haematology, Aarhus University Hospital, 9000 Aalborg, Denmark
3 Research Laboratory for Orthopaedic Surgery, Aarhus University Hospital, 8000 Aarhus, Denmark
The publication has been published in Regenerative Medicine, Juli, 2009
| | | | 06/07/09 Research assistants for the summer
This summer four medical students have been employed as research assistants to contribute to the ongoing research at the Department of Haematology. Common for all projects are the use of Affymetrix gene expression data as well as B-cell differentiation: - Jakob Virenfeldt (June 23 – September 15) is focusing on haematopoetic differentiation and their involvement in lymphomagenesis.
- Katrine Gade (May 15 – September 30) will be working on characterization of B-cell markers by flow cytometry and gene expression analysis of haematopoietic cell lines.
- Sofie Hallager (June 23 – December 31) is working with analyzing and comparing gene expression in embryonic stem cells, B-cell lines, normal B-cells and normal tissue cells.
- Jonas Svenningsen (June 23 – August 21) is working with identification of disease specific genes in haematological cancers by in silico analysis with the corresponding cell lines.
| | | | 02/07/09 Flow Cytometry Manager
The Department of Hematology has announced a job opportunity for a Flow Cytometry Manager to manage the Cell Sorting and Flow Cytometry Facilities within Aalborg Hospital Core function, providing technical and application support and expert advice.
Read the announcement and job description here.
| | | | 29/06/09 Myeloma Stem Cell Network status meeting 24.-26. June 2009 in Winchester.
Anne Dirks, Alex Schmitz, Martin Bøgsted, Kirsten H. Fogd, Hans E. Johnsen, Karen Dybkær and Linda Pilgaard took part in the biannual status meeting between the European partners of MSCNET. | | | | 16/06/09 Grant received
Professor Hans E Johnsen has received DKK 2,270,000 from Karen Elise Jensens Fond based on the project ”A new prognostic model fora cute myeloid leukemia based on flow cytometry, allows for identification of genes involved in disease progression and chemoresistence" (link to project summary).
| | | | 16/06/09 Invited speaker Karen Dybkaer has been invited as speaker at Mary Béve symposium on Pharmacogenetics, Nordic Society of Paediatric haematology and Oncology (NOPHO) 27th Annual meeting, Aarhus, Denmark, 5-9 June 2009
She will make a presentation with the title: Chemotherapy prediction in malignant lymphoma by genomic signature for drug sensitivity – from clinical guidance to pathogenetic understanding.Karen Dybkær, Aalborg | | | | 16/06/09 New ph.d. student
Maria Bro Kloster has been registered as ph.D student at The University of Aarhus Graduate School of Health Sciences 1 June 2009 with the project "The role of Pax5, BCL6, PRDM1 isoforms in B cell differentiation and malignancies | | | 12/06/09 New Publication Karen Dybkær and Hans Erik Johnsen are co-authors of a new publication: Loss of microRNA-targets in the 3'-untranslated region as a mechanism of retroviral insertional activation of Growth Factor Independence 1. Dabrowska MJ, Dybkær K, Johnsen HE, Wang B, Wabl M, Pedersen FS. The publication has been published in the Journal of Virology, May, 2009 | | | | 08/06/09 Laboratory stay at University of Salamanca, Spain Laboratory stay at University of Salamanca, Spain
The technicians Hanne T. Larsen, Rikke Barsdal and Helle Høholt and the scientists Alex Schmitz, Linda Pilgaard and Kirsten Fogd are visiting the “Banco Nacional de ADN” and the Flow Core Unit at the University of Salamanca. This is organized as part of our collaboration with the Cancer Research Center IBMCC at the University of Salamanca. The aim of the laboratory stay is to gain an insight into the practical and organizational aspects of the two core facilities. This will benefit the further development of the regional Biobank at the Department of Haematology, Aalborg Hospital.
| | | | 07/06/09 Invited speaker at the 14th Congress of the European Hematology Association Martin Bøgsted was invited speaker at the 14th Congress of the European Hematology Association, Berlin, Germany, June 4-7, 2009 and presented the talk Classifiers Predicting Response to Therapy. | | | | 04/06/09 Grant received Kirsten Fogd has received DKK 75 000 from Dansk Kræftforskningsfond towards the study ”Chemoresistance in Multiple Myeloma – development of chemoresistant cell lines for identifying candidate genes involved in drug-resistance” (link to project summary). | | | | 04/06/09 Ph.D. degree received August 29th 2008 Kirsten Fogd defended her PhD thesis “The effect of hypoxia on gene expression profiles of a human mesenchymal stem cell line undergoing osteogenic differentiation”.
The thesis was recommended for approval by a international assessment committee and November 12th 2008 the PhD title was awarded by the Academic Council at the University of Aalborg (AAU).
The thesis was written at the Laboratory for Stem Cell Research at the Department of Health Science and Technology at AAU, but Kirsten Fogd has been employed at the Department of Haematology since November 2007 as a postdoc.
Read English abstract.
| | | | 04/06/09 Grant received
The ph.d. students Maria Bro Kloster, Maria Bach Laursen, Kim Steve Bergkvist, Malene Krag Kjeldsen and Torben Lüth Andersson have each recived a stipendium of DKK 80.000 from Region Nordjylland. | | | | 04/06/09 Master defence Emilie Kallehauge will defence her master tuesday the 16th of june, from 13-15 at the Science Center, Aalborg.
Her project is titled: Regulation of Phenotypic Characteristics by MicroRNAs in Diffuse Large B cell Lymphoma See the abstract here. | | | | 18/05/09 Posters presented the 30/4 2009 at Science Day at the Science Center, Aalborg Hospital. The Department og Haematology had different research projects presented with posters on Science Day arranged by Aalborg Hospital. The following posters was presented at Science Day, the 30/4 2009.
Click on the titles below to see the posters:
| | | | 18/05/09 EU-information meeting concerning the EU 7th framework program. On May 13th, the Fundraising and Projectadministrationunit (FUPA) at Aalborg Sygehus in corporation with the EuroCenter hosted a meeting on future calls for health related research and development projects in the EU Seventh Framework Program. From The Department of Haematology, Research Laboratory Hans E. Johnsen, Kirsten Fogd, Alexander Schmitz, Linda Pilgaard, and Kim S. Bergkvist participated.
| | | 01/05/09 New publication A new publication by Karen Dybkaer: Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies. The article has been published in Leukemia and can be found here. See also publications. | | | 01/05/09 Ph.d. defence The 24.04.09 Linda Pillgaard defended her ph.d. : Investigating the effects of hypoxic preconditioning and reduced oxygen tension on in vitro chondrogenesis in human adipose tissuederived stem cells (ASCs)
Standardization of ASC isolation, optimization of chondrogenic
induction and the molecular effects of hypoxic preconditioning Read the abstract here. | | | 01/05/09 Ph.d. defence Kirsten Fogd has defended her ph.d. See the personal site of Kirsten here and the projectdescription here. | | | 01/05/09 Annual Report of 2008 The Annual Report of 2008 can be found here. | | | 24/04/09 Joint Haematological Spring Meeting Joint Haematological Spring Meeting 2009 for the North and Central region of Denmark. See program (in Danish). | | | 23/04/09 The Festival of Research (Forskningensdøgn) The Festival of Research is an annual national event organized by the Danish Agency for Science, Technology, and Innovation. It is intended to arouse public interest in and enhance public understanding of the methods, processes, and outcome of research and science. Kirsten Fogd is participating with the lecture "Når blodet går amok" (when the blood goes amok), which will address B-lymphocyte differentiation and haematological disorders derived from B-lymphocytes. Link to file (in Danish) | | | 23/04/09 Grant received Alex Schmitz was granted a support (legat) of 3500 DKK to participate in the Infinicyt-Workshop, 1st of April at the conference center at Stockholm airport, Sweden. | | | | 08/04/09 Phd. defence announced
Linda Pilgaard will defence her phd. project with the title: "Investigating the effects of hypoxic preconditioning and reduced oxygen tension on in vitro chondrogenesis in human adipose tissue-derived stem cells (ASCs)" the 24. of April, 13.00, at Bajers Vej 3B. The work has been done at the Laboratory of Stem Cell Research, Department for Health Science and Technology with Associate Professor Vladimir Zachar as advisor. | | | | 02/04/09 Student Programmer
A student programmer is needed in working with flow cytometric data. See the job description here. | | | | 28/03/09 New Associate Professor Karen Dybkær Sørensen has been employed as an Associate Professor at the Department of Haematology, Aalborg Hospital, Aarhus University.
| | | 27/03/09 Posters presented at the XII International Myeloma Workshop The following posters was presented at the XII International Myeloma Workshop. Clinical Impact of the European Myeloma Networg Guidelines EMN Poster 2009 Present Past Future Poster MSCNET 2009 Poster NMSG 13 03 2009 | | | 23/03/09 New publication Hans Erik Johnsen is main-author of a new published article: Double vs. single high dose melphalan 200 mg/m2 and autologous stem cell transplantation for multiple myeloma: a region-based study in 484 patients from the Nordic area Hans E. Johnsen, Bo Björkstrand, Tobias W. Klausen, Kari Remes, Astrid Gruber, Lene M. Knudsen, Olav J. Bergmann, Stig Lenhoff
Hematology Reviews 2009;1:e2 The publication has been published in Hematology Reviews. See the publication here. | | | 18/03/09 Grant Received Malene Krag Kjeldsen has recieved a grant from ''klinisk institut'' Århus University to finance a molecular Imager Chemi Doc TM XRS system. | | | 13/03/09 Participation at the 4th International qPCR Event Martin Bøgsted has attended the 4th International qPCR Event, Technische Universität München, March 9-13, 2009, and presented the talk "Design and analysis of Q-RT-PCR assays for haematological malignancies using mixed effects models" by Martin Bøgsted, Charlotte Mandrup, Anders Petersen, Steen Falgreen, Hans Erik Johnsen, Anne Bukh and Karen Dybkær. | | | 13/03/09 Grant received Martin Bøgsted has received a travel grant from "Den Obelske Familiefond", to support participation in the 4th International qPCR Event, Technische Universität, München, March 9-13, 2009. | | | 04/03/09
Meeting in the laboratory group of The Danish Myeloma Study Group (DMGS)
The initial goal of DMGS is to establish a national biobank containing material from myeloma patients. On March 4th, the laboratory subgroup of DMGS meet at the Department of Clinical Pathology, Odense University Hospital to discuss the practical details of collecting, handling and storing the biologic material. From the Haematology BioBank, Linda Pilgaard and Torben L. Andersson participated. | | | 06/03/2009 Posters for IWMM Four posters have been sent to the IWMM in Washington, USA. | | | 25/02/2009 Phd-project The Department of Hematology has announced an optional phd-project. See more here (in danish). | | | 09/02/2009 Co-financed PhD scholarships 2009 Two phd projects in haematology are announced at http://www.health.au.dk/medias/media8809.pdf.
| | | | | 03/02/2009 Participation in The European Myeloma Network Gene Expression Profiling workshop 30.-31. January 2009 in Rotterdam.
Anne Dirks, Martin Bøgsted, Kim S. Bergkvist, Hans E. Johnsen and Linda Pilgaard took part in the workshop where the aim was to discuss viewpoints on gene expression profiling by microarray from preparation to analysis from myeloma study groups across Europe, including the groups of Dirk Hose, Antonino Neri, Gareth Morgan, Herve Avet-Loiseau, Hans Johnsen and Pieter Sonneveld.
| | | 28/01/2009 Poster Presentation
On 16.01.2009 Charlotte Mandrup Ozimek presented a poster at the PhD day Faculty of Health Sciences Aarhus University. See the presentation here. | | | 28/01/2009 Poster Presentation
On 16.01.2009 Malene Krag Kjeldsen presented a poster at the PhD day Faculty of Health Sciences Aarhus University. See the presentation here. | | | 26/01/2009 Poster Presentation
On 16.01.2009 Anders Petersen presented a poster at the PhD day Faculty of Health Sciences Aarhus University. See the presentation here.
| | | 20/01/2009 New publication Karen Dybkær Sørensen is co-author in a new publication: Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies. Javeed Iqbal1, Can Kucuk1, Ronald J. deLeeuw, Gopesh Srivastava, Wayne Tam, Huimin Geng, David Klinkebiel, Judith K. Christman, Kavita Patel, Kajia Cao, Lijun Shen, Karen Dybkaer, Ivy F.L. Tsui, Hesham Ali, Norio Shimizu, Wing Yan Au, Wan L. Lam and Wing C. Chan
See more at Publications. | | | 20/01/2009 Call for SMVs to analyse the chemo sensitivity mechanisms of cancer cells.
CHEPRE invites SMV to a coorporation in a scientific project. See the profile description here. | | | 14/01/2009 Genomic Analyses Reveal Global Functional Alterations That Promote Tumor Growth and Novel Tumor Suppressor Genes in Natural Killer-Cell Malignancies "Genomic Analyses Reveal Global Functional Alterations That Promote Tumor Growth and Novel Tumor Suppressor Genes in Natural Killer-Cell Malignancies" was presented as poster at the ASH. See abstract here. | | | 13/01/2009 Scholarship from "Kræftens Bekæmpelse" Master student in Medical Biotechnology, Emilie Kallehauge, has received a scholarship of 70.000 DKK from "Kræftens Bekæmpelse" for the project: "Regulation of phenotypic characteristics by microRNAs in diffuse large B-cell lymphomas". The aim of the project is to study the expression of three specific microRNAs which is differentially expressed in normal lymphoid tissue, DLBCL cell lines, and DLBCL tumours by qPCR and global microRNA arrays. The effect of the microRNAs overexpression or down regulation on cancer relevant processes as apoptosis, cell cycle and proliferation will be examined by transfection mediated knockdown or overexpression studies of each microRNA in DLBCL cell lines. |
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