Updated on: 24.08.15

WELCOME

 The Haematology Research Laboratory

 

 

At the Hematological Research Laboratory, Aalborg University Hospital, we strive to explore the molecular mechanisms that underlie cellular function and contribute to human disease. In a multidisciplinary effort that spans molecular biology, medicine, and biostatistics we aim at deconstructing cellular differentiation derived chemotherapy resistance as a driver of cancer progression in several hematological malignancies and translate these discoveries into new diagnostic, prognostic and predictive characteristics.
 

 

The Hematological Research Laboratory integrate cell analysis, genome scale high throughput technologies, functional single gene analysis and biostatistics combined with computational modeling in our approach to link cellular differentiation, disease development and chemotherapy resistance.



Our mission is through research to ensure hematological patients the optimal diagnosis and treatment. We pursue this by focusing on specific areas of research where we can increase the understanding of the mechanisms behind the initiation and development as well as intrinsic or acquired treatment resistance of malignant hematological cancers. We develop methods for the determination of individual resistance rating and aim at creating evidence of clinical efficacy for implementation.



The Hematological Research Laboratory has a biobank where retrospective biomaterials collected from incoming patients at time of diagnosis from Region Nord to Aalborg University Hospital are stored with approval from the local ethic committee. Normal reference bio-material like mononuclear cells from peripheral blood, bone marrow, non-malignant lymph nodes, thymus, spleen and tonsils are likewise stored with approval from the local ethic committee.

 

Available equipment, measurement techniques etc.
 

  • Agilent’s Bioanalyzer and Nano-Drop to validate RNA integrity and concentration,
  • Affymetrix GeneChip System is established to run microarrays.
  • Mx3000 and a Ligthcycler used for real time qPCR.
  • Microtiter plate reader Optima-Fluostar used for systematic dose response screens monitoring GI50 via absorbance measurements of proliferation and systematic transfections of cell cultures.
  • A flow cytometry facility containing a FACSaria and a FACS Canto allowing single cell analysis and sorting.
  • A classified cell culture laboratory with incubators and LAF-benches enables set-up of in vitro assays.
  • Gel electrophoresis, blotting and imaging equipments used for fragment analysis, band quantification and ChIP.

 

Research areas and ongoing studies:

  • Leukemias, lymphomas and multiple myeloma.
  • Cellular differentiation.
  • Chemotherapy resistance.
  • Global genome and transcriptome analysis.
  • Functional single gene studies.
  • Biostatistic development of classification and prediction algorithms.

 

List of collaborators:

 

Haematological departments

  • Rigshospitalet
  • Århus Universitetshospital
  • Odense Universitetshospital
  • Herlev Hospital
  • Roskilde Sygehus
  • Vejle Sygehus


DMCG

  • Dansk Lymfom Gruppe (DLG)
  • Akut Leukæmi Gruppe (ALG)
  • Dansk Studiegruppe for Myeloproliferative Sygdomme (DSKMS)
  • Dansk Myelomatose Studiegruppe (DMSG)

 

Research

  • Erasmus Medical Center, Rotterdam
  • Vrij University, Brüssel
  • Royal Marsden, London
  • Salamanca University
  • University of Texas MD Anderson, Houston
  • University of Nebraska Medical Center, Omaha
  • University of Cambridge
  • Masaryk University, Brno, Czech Republic
  • Department of Molecular Biology and Genetics, Aarhus University
  • Department of Biomedicine - Department of Human Genetics, Aarhus University
  • Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University


Cooperation - clinical protocols

 

  • Hemato-Oncologie voor Volwassenen Nederland (HOVON)
  • Nordic Lymphoma Groupm NLG)
  • Nordisk Myelomatose Studie Gruppe (NMSG)
  • Nordic MDS-Group
  • Cardiff University
  • University of Birmingham

     

 

Research Fellowship at Stanford University Medical Center, California »

  22 June 2015   Research Fellowship at Stanford University Medical Center, California   From 1 September 2015 – end of June… »

Grant from Region Nordjyllands Forskningsfond 2015 »

15 June 2015 Grants from Region Nordjyllands Forskningsfond   Andreas Rasmussen has received a grant from Region Nordjyllands Forskningsfond for DKK… »

PhD course at Hindsgavl 12-13 March 2015 »

  26 March 2015   Annual National Haematological PhD Course on 12-13 March 2015 at Hindsgavl   Karen Dybkær participated as… »

Stay at UV University Medical Center, The Netherlands »

19 March 2015 Stay at VU University Medical Center, the Netherlands   From 1 February - 28 February 2015 PhD student Anders Ellern Bilgrau visited Carel F.W.… »

ESH conference in Thessaloniki, Greece 14-16 Nov 2014 »

20 November 2014 ESH Conference in Thessaloniki, Greece   Karen Dybkær, Maria Bach Laursen and Sara Correia Marques participated in… »

Grant from Hasselbalch & Lykkegaard Andersens Forskningsfond »

10 October 2014 Grant from Hasselbalch & Lykkegaard Andersens Forskningsfond    Staff specialist Tarec Christoffer El-Galaly has received a grant from Hasselbalch &… »

Poster presentations ASH »

10 October 2014 4 posters and one oral presentation at ASH in San Fransisco on 6-9 December 2014   Department of… »

PhD Course 20-23 October 2014 at Forskningens Hus »

25 September 2014   PhD Course on 20-23 October 2014 at Aalborg University Hospital, Forskningens Hus   A PhD course with the title… »

Poster award ESCCA 2014 Alex »

  22 September 2014   Poster award   Alexander Schmitz participated in the ESCCA 14th Euroconference on Clinical Cell Analysis… »

Grant from Herta Christensens Fond »

10 September 2014 Grant from Herta Christensens Fond    Maria Bach Laursen has received a grant from Herta Christensens Fond for… »

EHA SWG meeting Barcelona 5-7 Sept 2014 »

10 September 2014   EHA-SWG Scientific Meeting on Multiple Myeloma on 5-7 September 2014, Barcelona, Spain   Professor Hans E Johnsen… »

Research students 2014 »

  31 August 2014   Research students during the summer period   Laura Krogh Jørgensen, medical student, has been working as… »

Aalborg University Hospital | Deptartment of Haematology | Sdr. Skovvej 15 | DK-9000 Aalborg | Denmark | Tel.+4597663864  | Fax +4597666323 | E-mail: info@blodet.dk