Updated on: 11.09.14

WELCOME

 The Haematology Research Laboratory

 

 

At the Hematological Research Laboratory, Aalborg University Hospital, we strive to explore the molecular mechanisms that underlie cellular function and contribute to human disease. In a multidisciplinary effort that spans molecular biology, medicine, and biostatistics we aim at deconstructing cellular differentiation derived chemotherapy resistance as a driver of cancer progression in several hematological malignancies and translate these discoveries into new diagnostic, prognostic and predictive characteristics.
 

 

The Hematological Research Laboratory integrate cell analysis, genome scale high throughput technologies, functional single gene analysis and biostatistics combined with computational modeling in our approach to link cellular differentiation, disease development and chemotherapy resistance.



Our mission is through research to ensure hematological patients the optimal diagnosis and treatment. We pursue this by focusing on specific areas of research where we can increase the understanding of the mechanisms behind the initiation and development as well as intrinsic or acquired treatment resistance of malignant hematological cancers. We develop methods for the determination of individual resistance rating and aim at creating evidence of clinical efficacy for implementation.



The Hematological Research Laboratory has a biobank where retrospective biomaterials collected from incoming patients at time of diagnosis from Region Nord to Aalborg University Hospital are stored with approval from the local ethic committee. Normal reference bio-material like mononuclear cells from peripheral blood, bone marrow, non-malignant lymph nodes, thymus, spleen and tonsils are likewise stored with approval from the local ethic committee.

 

Available equipment, measurement techniques etc.

Nutritional assessments:

  • Agilent’s Bioanalyzer and Nano-Drop to validate RNA integrity and concentration,
  • Affymetrix GeneChip System is established to run microarrays.
  • Mx3000 and a Ligthcycler used for real time qPCR.
  • Microtiter plate reader Optima-Fluostar used for systematic dose response screens monitoring GI50 via absorbance measurements of proliferation and systematic transfections of cell cultures.
  • A flow cytometry facility containing a FACSaria and a FACS Canto allowing single cell analysis and sorting.
  • A classified cell culture laboratory with incubators and LAF-benches enables set-up of in vitro assays.
  • Gel electrophoresis, blotting and imaging equipments used for fragment analysis, band quantification and ChIP.

 

Research areas and ongoing studies:

  • Leukemias, lymphomas and multiple myeloma.
  • Cellular differentiation.
  • Chemotherapy resistance.
  • Global genome and transcriptome analysis.
  • Functional single gene studies.
  • Biostatistic development of classification and prediction algorithms.

 

List of collaborators:

 

Haematological departments

  • Rigshospitalet
  • Århus Universitetshospital
  • Odense Universitetshospital
  • Herlev Hospital
  • Roskilde Sygehus
  • Vejle Sygehus


DMCG

  • Dansk Lymfom Gruppe (DLG)
  • Akut Leukæmi Gruppe (ALG)
  • Dansk Studiegruppe for Myeloproliferative Sygdomme (DSKMS)
  • Dansk Myelomatose Studiegruppe (DMSG)

 

Research

  • Erasmus Medical Center, Rotterdam
  • Vrij University, Brüssel
  • Royal Marsden, London
  • Salamanca University
  • University of Texas MD Anderson, Houston
  • University of Nebraska Medical Center, Omaha
  • University of Cambridge
  • Masaryk University, Brno, Czech Republic
  • Department of Molecular Biology and Genetics, Aarhus University
  • Department of Biomedicine - Department of Human Genetics, Aarhus University
  • Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University


Cooperation - clinical protocols

 

  • Hemato-Oncologie voor Volwassenen Nederland (HOVON)
  • Nordic Lymphoma Groupm NLG)
  • Nordisk Myelomatose Studie Gruppe (NMSG)
  • Nordic MDS-Group
  • Cardiff University
  • University of Birmingham

     

 

Grant from Herta Christensens Fond »

10 September 2014 Grant from Herta Christensens Fond    Maria Bach Laursen has received a grant from Herta Christensens Fond for… »

EHA SWG meeting Barcelona 5-7 Sept 2014 »

10 September 2014   EHA-SWG Scientific Meeting on Multiple Myeloma on 5-7 September 2014, Barcelona, Spain   Professor Hans E Johnsen… »

Research students 2014 »

  31 August 2014   Research students during the summer period   Laura Krogh Jørgensen, medical student, has been working as… »

ASH meeting on Lymphoma Biology »

26 August 2014   ASH meeting on Lymphoma Biology on 10-13 August 2014, Colorado Springs, Colorado   Malene Krag Kejldsen participated in… »

PhD thesis defence Kim Steve Gerlach Bergkvist 26.09.14 »

  22 August 2014 PhD thesis - Kim Steve Gerlach Bergkvist, 26 September 2014 On Friday 26 September 2014, MSc Eng. Kim Steve Gerlach Bergkvist,… »

Annual meeting at Klinisk Kræftforskningscenter April 2014 »

  30 April 2014   Annual meeting at Klinisk Kræftforskningscenter, Klitgaarden Refugium, Skagen   The Clinical Cancer Research Center (Klinisk Kræftforskningscenter)… »

Annual National Haematological PhD Course at Hindsgavl »

18 March 2013   Annual National Haematological PhD Course at Hindsgavl on 14 and 15 March 2013   and  … »

Grant from Region Nordjyllands Forskningsfond »

28 March 2014 Grant from Region Nordjyllands Forskningsfond Julie Støve Bødker has received a grant from Region Nordjyllands Forskningsfond for DKK 100,000… »

PhD thesis defence Steffen Falgreen Larsen 14.03.14 »

17 March 2014 PhD thesis - Steffen Falgreen Larsen, 14 March 2014 On Friday 14 March 2014, MSc Steffen Falgreen Larsen,… »

PhD course at Hindsgavl 13-14 March 2014 »

16 March 2014   Annual National Haematological PhD Course on 13-14 March 2014 and Annual Meeting at Danish Haematological Society… »

PhD thesis defence Maria Bach Laursen 07.03.14 »

10 March 2014   PhD thesis - Maria Bach Laursen, 7 March 2014   On Friday 7 March 2014, MSc Maria… »

Course in Cambridge on 17 - 18 February 2014 »

7 March 2014   Course in Cambridge on 17-18 February 2014    Martin Bøgsted participated in the course 'Making sense of… »

Aalborg University Hospital | Deptartment of Haematology | Sdr. Skovvej 15 | DK-9000 Aalborg | Denmark | Tel.+4597663864  | Fax +4597666323 | E-mail: info@blodet.dk