The Haematology Research Laboratory
At the Hematological Research Laboratory, Aalborg University Hospital, we strive to explore the molecular mechanisms that underlie cellular function and contribute to human disease. In a multidisciplinary effort that spans molecular biology, medicine, and biostatistics we aim at deconstructing cellular differentiation derived chemotherapy resistance as a driver of cancer progression in several hematological malignancies and translate these discoveries into new diagnostic, prognostic and predictive characteristics.
The Hematological Research Laboratory integrate cell analysis, genome scale high throughput technologies, functional single gene analysis and biostatistics combined with computational modeling in our approach to link cellular differentiation, disease development and chemotherapy resistance.
Our mission is through research to ensure hematological patients the optimal diagnosis and treatment. We pursue this by focusing on specific areas of research where we can increase the understanding of the mechanisms behind the initiation and development as well as intrinsic or acquired treatment resistance of malignant hematological cancers. We develop methods for the determination of individual resistance rating and aim at creating evidence of clinical efficacy for implementation.
The Hematological Research Laboratory has a biobank where retrospective biomaterials collected from incoming patients at time of diagnosis from Region Nord to Aalborg University Hospital are stored with approval from the local ethic committee. Normal reference bio-material like mononuclear cells from peripheral blood, bone marrow, non-malignant lymph nodes, thymus, spleen and tonsils are likewise stored with approval from the local ethic committee.
Available equipment, measurement techniques etc.
- Agilent’s Bioanalyzer and Nano-Drop to validate RNA integrity and concentration,
- Affymetrix GeneChip System is established to run microarrays.
- Mx3000 and a Ligthcycler used for real time qPCR.
- Microtiter plate reader Optima-Fluostar used for systematic dose response screens monitoring GI50 via absorbance measurements of proliferation and systematic transfections of cell cultures.
- A flow cytometry facility containing a FACSaria and a FACS Canto allowing single cell analysis and sorting.
- A classified cell culture laboratory with incubators and LAF-benches enables set-up of in vitro assays.
- Gel electrophoresis, blotting and imaging equipments used for fragment analysis, band quantification and ChIP.
Research areas and ongoing studies:
- Leukemias, lymphomas and multiple myeloma.
- Cellular differentiation.
- Chemotherapy resistance.
- Global genome and transcriptome analysis.
- Functional single gene studies.
- Biostatistic development of classification and prediction algorithms.
List of collaborators:
- Århus Universitetshospital
- Odense Universitetshospital
- Herlev Hospital
- Roskilde Sygehus
- Vejle Sygehus
- Dansk Lymfom Gruppe (DLG)
- Akut Leukæmi Gruppe (ALG)
- Dansk Studiegruppe for Myeloproliferative Sygdomme (DSKMS)
- Dansk Myelomatose Studiegruppe (DMSG)
- Erasmus Medical Center, Rotterdam
- Vrij University, Brüssel
- Royal Marsden, London
- Salamanca University
- University of Texas MD Anderson, Houston
- University of Nebraska Medical Center, Omaha
- University of Cambridge
- Masaryk University, Brno, Czech Republic
- Department of Molecular Biology and Genetics, Aarhus University
- Department of Biomedicine - Department of Human Genetics, Aarhus University
- Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University
Cooperation - clinical protocols
- Hemato-Oncologie voor Volwassenen Nederland (HOVON)
- Nordic Lymphoma Groupm NLG)
- Nordisk Myelomatose Studie Gruppe (NMSG)
- Nordic MDS-Group
- Cardiff University
- University of Birmingham
25 January 2016 Stay at Stanford
Martin Bøgsted, Professor MSO, is going to Stanford at the end of January… »
18 January 2016 Grant from Det Obelske Familefond
Senior researcher Julie Støve Bødker and flow cytometry core… »
28 December 2015 PhD thesis - Kaspar René Nielsen, 14 December 2015
On Monday 14 December 2015 physician… »
10 November 2015 PhD thesis - Sara Correia Marques, 27 November 2015
On Friday 27 November 2015 MPharm Sara… »
8 November 2015 PhD Course on 10-12 November 2015 at Klitgaarden, Skagen
A PhD course with the title "… »
9 September 2015 Grant from the Danish Cancer Society
Consultant haematologist Tarec Christoffer El-Galaly has received a grant… »
8 September 2015 Inaugural reception of the Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, on 8… »
22 June 2015 Research Fellowship at Stanford University Medical Center, California
From 1 September 2015 – end of June… »
15 June 2015 Grants from Region Nordjyllands Forskningsfond
Andreas Rasmussen has received a grant from Region Nordjyllands Forskningsfond for DKK… »
26 March 2015 Annual National Haematological PhD Course on 12-13 March 2015 at Hindsgavl
Karen Dybkær participated as… »