Updated on: 01.12.16

WELCOME

 The Haematology Research Laboratory

 

 

At the Hematological Research Laboratory, Aalborg University Hospital, we strive to explore the molecular mechanisms that underlie cellular function and contribute to human disease. In a multidisciplinary effort that spans molecular biology, medicine, and biostatistics we aim at deconstructing cellular differentiation derived chemotherapy resistance as a driver of cancer progression in several hematological malignancies and translate these discoveries into new diagnostic, prognostic and predictive characteristics.
 

 

The Hematological Research Laboratory integrate cell analysis, genome scale high throughput technologies, functional single gene analysis and biostatistics combined with computational modeling in our approach to link cellular differentiation, disease development and chemotherapy resistance.



Our mission is through research to ensure hematological patients the optimal diagnosis and treatment. We pursue this by focusing on specific areas of research where we can increase the understanding of the mechanisms behind the initiation and development as well as intrinsic or acquired treatment resistance of malignant hematological cancers. We develop methods for the determination of individual resistance rating and aim at creating evidence of clinical efficacy for implementation.



The Hematological Research Laboratory has a biobank where retrospective biomaterials collected from incoming patients at time of diagnosis from Region Nord to Aalborg University Hospital are stored with approval from the local ethic committee. Normal reference bio-material like mononuclear cells from peripheral blood, bone marrow, non-malignant lymph nodes, thymus, spleen and tonsils are likewise stored with approval from the local ethic committee.

 

Available equipment, measurement techniques etc.
 

  • Agilent’s Bioanalyzer and Nano-Drop to validate RNA integrity and concentration,
  • Affymetrix GeneChip System is established to run microarrays.
  • Mx3000 and a Ligthcycler used for real time qPCR.
  • Microtiter plate reader Optima-Fluostar used for systematic dose response screens monitoring GI50 via absorbance measurements of proliferation and systematic transfections of cell cultures.
  • A flow cytometry facility containing a FACSaria and a FACS Canto allowing single cell analysis and sorting.
  • A classified cell culture laboratory with incubators and LAF-benches enables set-up of in vitro assays.
  • Gel electrophoresis, blotting and imaging equipments used for fragment analysis, band quantification and ChIP.

 

Research areas and ongoing studies:

  • Leukemias, lymphomas and multiple myeloma.
  • Cellular differentiation.
  • Chemotherapy resistance.
  • Global genome and transcriptome analysis.
  • Functional single gene studies.
  • Biostatistic development of classification and prediction algorithms.

 

List of collaborators:

 

Haematological departments

  • Rigshospitalet
  • Århus Universitetshospital
  • Odense Universitetshospital
  • Herlev Hospital
  • Roskilde Sygehus
  • Vejle Sygehus


DMCG

  • Dansk Lymfom Gruppe (DLG)
  • Akut Leukæmi Gruppe (ALG)
  • Dansk Studiegruppe for Myeloproliferative Sygdomme (DSKMS)
  • Dansk Myelomatose Studiegruppe (DMSG)

 

Research

  • Erasmus Medical Center, Rotterdam
  • Vrij University, Brüssel
  • Royal Marsden, London
  • Salamanca University
  • University of Texas MD Anderson, Houston
  • University of Nebraska Medical Center, Omaha
  • University of Cambridge
  • Masaryk University, Brno, Czech Republic
  • Department of Molecular Biology and Genetics, Aarhus University
  • Department of Biomedicine - Department of Human Genetics, Aarhus University
  • Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University


Cooperation - clinical protocols

 

  • Hemato-Oncologie voor Volwassenen Nederland (HOVON)
  • Nordic Lymphoma Groupm NLG)
  • Nordisk Myelomatose Studie Gruppe (NMSG)
  • Nordic MDS-Group
  • Cardiff University
  • University of Birmingham

     

 

HST seminar on bioinformatics 27.10.16 at AAU »

  18 October 2016   HST seminar on 27 October 2016 at Aalborg University   Laboratory for Medical Mass Spectrometry… »

LVS, Århus, den 26. oktober 2016 »

  17 October 2016   LVS seminar on 26 October 2016 at Aarhus University   LVS, Organisationen af Lægevidenskabelige Selskaber,… »

PhD Course 24-27 October 2016 at Forskningens Hus »

  18 October 2016   PhD Course on 24-27 October 2016 at Aalborg University Hospital, Forskningens Hus   A PhD course with… »

Børsen Weekend, juli 2016 »

10 August 2016   Article in Børsen Weekend on 2 July 2016 Caroline Holm Nørgaard is… »

Folkemødet, Bornholm 16. juni 2016, Martin Bøgsted »

30 June 2016   Folkemødet at Bornholm on 16-19 June 2016   On 16 June 2016 Professor Martin… »

PhD thesis defence Liesbeth Bieghs 07.06.16 »

  27 June 2016 PhD thesis - Liesbeth Bieghs, 7 June 2016 On Tuesday 7 June 2016, master in… »

Newsletter from Caroline Holm Nørgaard June 2016 »

13  June 2016 Newsletter from medical student Caroline Holm Nørgaard at Stanford Univeristy Read more here     17 May… »

EHA Classical Master Class, Rie Sander Bech »

17 May 2016   EHA Classical Master Class   Haematologist, Rie Sander Bech participated in an EHA Master Class… »

Travel grant from Lundbeckfonden »

24 Febuary 2016   Travel grant from Lundbeckfonden   Professor MSO Martin Bøgsted has received a grant from Lundbeckfonden for… »

Newsletter from Caroline Holm Nørgaard Feb. 2016 »

22  February 2016 Newsletter from medical student Caroline Holm Nørgaard at Stanford Univeristy Read more here     »

Article in Dagens Medicin, februar 2016 »

17  February 2016 Article in Dagens Medicin concerning check-up scans of patients with lymphoma   Tarec Christoffer El-Galay, consultant… »

Article in Ingeniøren, februar 2016 »

12  February 2016 Article in Ingeniøren concerning personalized medicine   Martin Bøgsted, Professor MSO, has given an interview to… »

Stay at Stanford - Martin - end January 2016 »

25 January 2016 Stay at Stanford   Martin Bøgsted, Professor MSO, is going to Stanford at the end of January… »

Grant Julie / Alex Obelske Familiefond 2016 »

18 January 2016   Grant from Det Obelske Familefond   Senior researcher Julie Støve Bødker and flow cytometry core… »

PhD thesis defence Kaspar Rene Nielsen 14.12.15 »

  28 December 2015 PhD thesis - Kaspar René Nielsen, 14 December 2015 On Monday 14 December 2015 physician… »

PhD thesis defence Sara Correia Marques 27.11.15 »

  10 November 2015 PhD thesis - Sara Correia Marques, 27 November 2015 On Friday 27 November 2015 MPharm Sara… »

PhD Course 10-12 November 2015 at Klitgården, Skagen »

  8 November 2015   PhD Course on 10-12 November 2015 at Klitgaarden, Skagen   A PhD course with the title… »

Grants KB and KEJ Karen - KB Knæk Cancer Tarec »

9 September 2015   Grant from the Danish Cancer Society   Consultant haematologist Tarec Christoffer El-Galaly has received a grant… »

Åbningsreception på Center for RNA Medicine, AAU Sydhavnen »

  8 September 2015   Inaugural reception of the Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, on 8… »

Research Fellowship at Stanford University Medical Center, California »

  22 June 2015   Research Fellowship at Stanford University Medical Center, California   From 1 September 2015 – end of June… »

Aalborg University Hospital | Deptartment of Haematology | Sdr. Skovvej 15 | DK-9000 Aalborg | Denmark | Tel.+4597663864  | Fax +4597666323 | E-mail: info@blodet.dk